Supplementary tables from: Long-term outcomes of patients diagnosed with differentiated thyroid cancer in childhood and young adulthood
Data files
Oct 02, 2025 version files 5.75 KB
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README.md
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Supplemental_table1.csv
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Supplemental_table2.csv
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Supplemental_table3.csv
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Abstract
Rates of pediatric differentiated thyroid cancer (DTC) in the United States have been increasing while studies on this population remain limited by inconsistent age cut-offs, short follow-up periods, or relative lack of clinical data. In this manuscript, we report long-term outcomes in patients diagnosed with DTC at age 20 years old and younger.
155 patients were included with a median age at diagnosis of 17 years (9 to 20 years). The frequency of distant metastasis and larger tumor size were inversely related to age at diagnosis (overall stage p = 0.045, T-stage (size of the primary tumor ± invasion) p = 0.001). The median duration of follow-up was 16 years (1 to 63 years) and at last follow-up, 52.3% of patients had excellent response and disease specific mortality was 0%. There was no difference in response to therapy based on histologic subtype or birth sex; however, younger age at diagnosis was associated with worse response (p = 0.046). Patients with over 50 years of follow-up (n = 9) had median of 36 years of stability, with progression occurring in 6 out of 9 (67%) patients.
Dataset DOI: 10.5061/dryad.wdbrv162j
Description of the data and file structure
These tables contain demographic, staging, treatment, and response data of patients diagnosed with differentiated thyroid cancer at age 20 years or younger (who were enrolled in an IRB approved protocol) who had family history of thyroid cancer and of those who were diagnosed with additional cancers. Also contain clinical and PV/LPV information on a subset of patients.
Files and variables
Abbreviations:
DTC: differentiated thyroid cancer; PTC: papillary thyroid cancer; FTC: follicular thyroid cancer; FNMTC: familial non medullary thyroid cancer; RAI: radioactive iodine; mCi: millicurie; PV: pathogenic variant; LPV: likely pathogenic variant
File: Supplemental_table1.csv
Description: Demographic, staging, treatment, and response data of the patients with family history of thyroid cancer.
File: Supplemental_table2.csv
Description: Demographic, staging, treatment, and response data of the patients diagnosed with additional cancers.
File: Supplemental_table3.csv
Description: Clinical data and germline analysis (n=11).
Code/software
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Access information
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Human subjects data
All patients provided written informed consent to one or both IRB-approved biorepository protocols. Both consent forms include information about de-identified data being shared for educational or research purposes. No personally identifiable information is included in this submission.