Data and code from: Viscoelasticity explains fast adaptation in the auditory amplifiers of mammals
Data files
Nov 26, 2025 version files 3.97 KB
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A_14pts_Peng13Fig4H.csv
340 B
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Ppeak_Peng13Fig1a.csv
50 B
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Ppeak_Peng13Fig2a.csv
51 B
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Ppeak_Peng13Fig4a.csv
51 B
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Prest_Peng13FigS3C.csv
313 B
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R_14pts_Peng13Fig4G.csv
365 B
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README.md
1.98 KB
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Shift_Peng13Fig6C.csv
106 B
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tau1_14pts_Peng13Fig4E.csv
363 B
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tau2_14pts_Peng13Fig4F.csv
357 B
Abstract
When we hear, sound-induced deflections of our sensory outer-hair-cell bundles are transduced into receptor currents. These receptor currents drive the cochlear amplifier, which is required for our ear's high sensitivity, broad dynamic range, and sharp frequency selectivity. Adaptation maintains the sensitivity of receptor currents to bundle deflections, but the mechanisms underlying adaptation in outer-hair-cell bundles remain under debate, and how adaptation works at physiologically relevant frequencies is unclear. We propose a mechanism for the fastest components of adaptation, based on viscoelastic adaptation elements. To evaluate this proposal, we fit a mathematical model of an outer-hair-cell bundle with viscoelastic adaptation elements to twelve independent experimental observations. We validate the model by successfully predicting an observation not used for fitting --- how much receptor-current sensitivity is maintained by fast adaptation. The experimentally constrained model predicts the effects of fast adaptation for physiologically relevant frequencies. We show that there is considerable deflection-current hysteresis, the receptor current can lead the bundle deflection to a large extent (up to 61° phase lead), and that fast adaptation greatly high-pass filters the receptor current. Owing to viscoelastic fast adaptation, the dynamic range of the outer-hair-cell bundle depends on the stimulus frequency. These predictions and others are experimentally testable. Because viscoelastic fast adaptation substantially affects receptor-current sensitivity, hysteresis, phase leads, high-pass filtering, and dynamic range, we expect viscoelastic fast adaptation to greatly impact the cochlear amplifier and hearing. Here, we provide the experimental data used to constrain the mathematical models and the modeling code.
Dataset DOI: 10.5061/dryad.w3r22813p
Description of the data and file structure
Description of the data and file structure
The data is in CSV format and can be read by any text editor. These data are measured values for different hair bundles.
Files and variables
A_14pts_Peng13Fig4H.csv contains adaptation extent values.
Ppeak_Peng13Fig1a.csv contains peak current values.
Ppeak_Peng13Fig2a.csv contains peak current values.
Ppeak_Peng13Fig4a.csv contains peak current values.
Prest_Peng13FigS3C.csv contains resting current values.
R_14pts_Peng13Fig4G.csv contains long timescale fraction values.
Shift_Peng13Fig6C.csv contains adaptation shift values.
tau1_14pts_Peng13Fig4E.csv contains short timescale values.
tau2_14pts_Peng13Fig4F.csv contains long timescale values.
Code/software
Mathematica 14 or later, or the free Wolfram Player will open the nb files. The data files are read in by the nb code files.
Part1_calibration_phasors.nb fits the data and calculates model results.
Part2_hysteresis.nb calculates model hysteresis.
Part3_freq_analysis.nb calculates model frequency responses.
Part4_shift.nb calculates the modle adaptation shift.
Part5_change_params_compare_fits.nb calculates adaptation time series owing to parameter variation.
Part6_change_params_compare_shifts.nb caculates shifts owing to parameter variation.
Part7_stiffnesss_increase.nb calculates the bundle stiffness and resting deflection when the adaptation stiffnesses are doubled.
Part8_hysteresis_stiffness_increase.nb calculates model hysteresis when the adaptation stiffnesses are doubled.
Part9_freq_analysis_stiffness_increase.nb calculates model frequency responses when the adaptation stiffnesses are doubled.
Access information
Data was derived from the following sources:
- Peng et al. (2013) Neuron 80.
