Objective: To evaluate the evidence on the efficacy of psychosocial interventions for improving pregnancy rates and reducing distress for couples in treatment with assisted reproductive technology (ART). Design: Systematic review and meta-analysis. Data sources PsycINFO, PubMed, Embase, CINAHL, Web of Science and The Cochrane Library between 1978 and April 2014. Study selection Studies were considered eligible if they evaluated the effect of any psychosocial intervention on clinical pregnancy and/or distress in infertile participants, used a quantitative approach, and were published in English. Data extraction Study characteristics and results were extracted and the methodological quality assessed. Effect sizes (Hedges g) were pooled using a random effect model. Heterogeneity was assessed using the Q statistic and I2, and publication bias evaluated using Eggers’ method. Possible moderators and mediators were explored with meta-ANOVAs and meta-regression. Results We identified 39 eligible studies (total N = 2746 men and women) assessing the effects of psychological treatment on pregnancy rates and/or adverse psychological outcomes, including depressive symptoms, anxiety, infertility stress, and marital function. Statistically significant and robust overall effects of psychosocial intervention were found for both clinical pregnancy (RR = 2.01; CI: 1.48-2.73; p<0.001) and combined psychological outcomes (Hedges g=0.59; CI: 0.38-0.80; p=0.001,). The pooled effect sizes (ES) for psychological outcomes were generally larger for women (g: 0.51-0.73) than men (0.13-0.34), but the difference only reached statistical significance for depressive symptoms (p=0.004). Meta-regression indicated that larger reductions in anxiety were associated with greater improvement in pregnancy rates (Slope: 0.19; p=0.004). No clear-cut differences were found between effects of cognitive behavioral therapy (CBT) (g=0.84), mind-body interventions (0.61), and other intervention types (0.50). Conclusion The present meta-analysis suggests that psychosocial interventions for couples in treatment for infertility, in particular CBT, could be efficacious, both in reducing psychological distress and in improving clinical pregnancy rates.