Data from: Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's Disease - implications for space travel

Rudobeck E, Bellone JA, Szücs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinsky R

Date Published: December 5, 2017

DOI: https://doi.org/10.5061/dryad.0008d

Files in this package

Content in the Dryad Digital Repository is offered "as is." By downloading files, you agree to the Dryad Terms of Service. To the extent possible under law, the authors have waived all copyright and related or neighboring rights to this data. CC0 (opens a new window) Open Data (opens a new window)

Title Fig 2 WM swim distance raw data
Downloaded 4 times
Description Swim Distance in Water Maze in APP/PS1 TG and WT mice irradiated with protons measured pre-, 3 and 6 months postirradiation
Download Fig 2 WM swim distance raw data.xlsx (20.77 Kb)
Details View File Details
Title Fig 3 and S3Fig Input Output Curves at Max and Full Stimualtion intesities
Downloaded 2 times
Description I-O functions in CA1 neurons in slices from TG and WT mice 9 months post-irradiation.
Download Fig 3 and S3Fig Input Output Curves at Max....xlsx (101.5 Kb)
Details View File Details
Title Fig 4 Paired-Pulse Facilitation in TG and WT mice at 9 months
Downloaded 1 time
Description PPF in CA1 neurons of TG and WT mice 9 months post-irradiation. PPF ratios are shown at all tested inter-stimulus intervals (ISI) of 20-400 ms.
Download Fig 4 Paired-Pulse Facilitation in TG and ....xlsx (12.05 Kb)
Details View File Details
Title Fig 5 Paired-Pulse Facilitation in TG at 6 and 9 months
Downloaded 1 time
Description Radiation effects on age-related increase of PPF in TG mice. Comparison of PPF between at 6 and 9 months in TG mice revealed significant interaction between radiation dose and post-irradiation time point with enhanced PPF in 9-month TG control group only. Note that the graph indicates PPF values acquired at 20 ms only (strongest PPF effect); however, the statistical model included PPF recorded at all ISIs.
Download Fig 5 Paired-Pulse Facilitation in TG at 6....xlsx (10.08 Kb)
Details View File Details
Title Fig 6 Paired-Pulse Inhibition of PS in TG and WT mice at 9 months
Downloaded 1 time
Description Although the bar graph indicates PPI values acquired at 6 ms; the statistical model included PPI recorded at all ISIs
Download Fig 6 Paired-Pulse Inhibition of PS in TG ....xlsx (12.45 Kb)
Details View File Details
Title Fig 7. IHC analyses of Abeta deposits in TG mice 9 months post-irradiation
Downloaded 1 time
Description Immunohistochemical analyses of Abeta deposition analyses of Aβ deposits in TG APP/PS1 mice 9 months post-irradiation.
Download Fig 7. IHC analyses of Abeta deposits in T....xlsx (10.63 Kb)
Details View File Details
Title Fig 8. WB analyses of synaptophysin in the cortex of TG and WT mice at 9 months
Description Western Blot analyses of synaptophysin in the cortex of TG and WT mice 9 months post-irradiation.
Download Fig 8. WB analyses of synaptophysin in the....xlsx (8.636 Kb)
Details View File Details
Title Fig 9. Cytokine levels in the cortex of TG and WT mice 9 months post-irradiation.
Downloaded 2 times
Description Luminex analyses of cytokine levels in the cortex of TG and WT mice 9 months post-irradiation.
Download Fig 9. Cytokine levels in the cortex of TG....xlsx (17.27 Kb)
Details View File Details

When using this data, please cite the original publication:

Rudobeck E, Bellone JA, Szücs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinský R (2017) Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease – Implications for space travel. PLOS ONE 12(11): e0186168. https://doi.org/10.1371/journal.pone.0186168

Additionally, please cite the Dryad data package:

Rudobeck E, Bellone JA, Szücs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinsky R (2017) Data from: Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's Disease - implications for space travel. Dryad Digital Repository. https://doi.org/10.5061/dryad.0008d
Cite | Share
Download the data package citation in the following formats:
   RIS (compatible with EndNote, Reference Manager, ProCite, RefWorks)
   BibTex (compatible with BibDesk, LaTeX)

Search for data

Be part of Dryad

We encourage organizations to: