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dc.contributor.author O’Keefe, Stephen J. D.
dc.contributor.author Li, Jia V.
dc.contributor.author Lahti, Leo
dc.contributor.author Ou, Junhai
dc.contributor.author Carbonero, Franck
dc.contributor.author Khaled, Mohammed
dc.contributor.author Posma, Joram M.
dc.contributor.author Kinross, James
dc.contributor.author Wahl, Elaine
dc.contributor.author Ruder, Elizabeth
dc.contributor.author Vipperla, Kishore
dc.contributor.author Naidoo, Vasudevan
dc.contributor.author Mtshali, Lungile
dc.contributor.author Tims, Sebastian
dc.contributor.author Puylaert, Philippe G. B.
dc.contributor.author DeLany, James
dc.contributor.author Krasinskas, Alyssa
dc.contributor.author Benefiel, Ann C.
dc.contributor.author Kaseb, Hatem O.
dc.contributor.author Newton, Keith
dc.contributor.author Nicholson, Jeremy K.
dc.contributor.author de Vos, Willem M.
dc.contributor.author Gaskins, H. Rex
dc.contributor.author Zoetendal, Erwin G.
dc.coverage.spatial South Africa
dc.coverage.spatial USA
dc.date.accessioned 2015-04-28T22:32:41Z
dc.date.available 2015-04-28T22:32:41Z
dc.date.issued 2015-04-28
dc.identifier doi:10.5061/dryad.1mn1n
dc.identifier.citation O’Keefe SJD, Li JV, Lahti L, Ou J, Carbonero F, Khaled M, Posma JM, Kinross J, Wahl E, Ruder E, Vipperla K, Naidoo V, Mtshali L, Tims S, Puylaert PGB, DeLany J, Krasinskas A, Benefiel AC, Kaseb HO, Newton K, Nicholson JK, de Vos WM, Gaskins HR, Zoetendal EG (2015) Fat, fibre and cancer risk in African Americans and rural Africans. Nature Communications 6: 6342.
dc.identifier.uri http://hdl.handle.net/10255/dryad.78877
dc.description Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.
dc.relation.haspart doi:10.5061/dryad.1mn1n/1
dc.relation.haspart doi:10.5061/dryad.1mn1n/2
dc.relation.haspart doi:10.5061/dryad.1mn1n/3
dc.relation.isreferencedby doi:10.1038/ncomms7342
dc.relation.isreferencedby PMID:25919227
dc.subject microbiota
dc.subject HITChip
dc.subject genera
dc.title Data from: Fat, fibre and cancer risk in African Americans and rural Africans
dc.type Article
prism.publicationName Nature Communications

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Title HITChip data matrix
Downloaded 42 times
Description A csv file containing HITChip phylogenetic microarray data matrix for the study samples. The data provides the absolute HITChip phylogenetic microarray signal estimate for 130 genus-like groups, preprocessed as described in the main article.
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Title Metadata
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Description CSV file containing the sample metadata in the HITChip data matrix. The variables are rounded or aggregated to ensure subject anonymity. 'NA' refers to missing values. The variable units and other information are as follows: - SampleID: unique sample identified corresponding to samples in the HITChip data matrix - subject: Subject identifier (some subjects have multiple time points) - bmi: Standard body-mass classification (underweight: <18.5; lean: 18.5-25; overweight: 25-30; obese: 30-35; severe obese: 35-40; morbid obese 40-45; superobese >45). - sex (male/female) - nationality: African American (AAM); Native African (AFR) - timepoint.group: Time point (1/2) within the group (ED/HE/DI) - timepoint.total: Time point in the overall data set (ED1 - HE1 -HE2 - DI1 - DI2 - ED2 ie. 1- 2- 3- 4- 5- 6) - group: Sample treatment group: as described in the main article; Dietary intervention (DI) / Home environment (HE) / Solid stool pre-colonoscopy (ED)
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Title NMR data
Downloaded 86 times
Download JKNCRC_JLI121127_Okeefe.zip (108.4 Mb)
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