Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane

Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, Luo J

Date Published: October 30, 2014

DOI: http://dx.doi.org/10.5061/dryad.211gr

 

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Title MBP is toxic to primary hippocampal neurons in vitro
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Description Original data of statistical graph in Figure 1
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Title Toxicity of MBP relies on polypeptide basicity
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Description Original data of statistical graph in Figure 4
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Title MBP depolarizes the resting membrane potential
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Description Original data of statistical graph in Figure 5
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Title MBP induces cation influx
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Description Original data of statistical graph in Figure 6
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Title MBP interferes with the fluidity of the neuronal plasma membrane
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Description Original data of statistical graph in Figure 7
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Title MBP directly disrupts the integrity of the lipid bilayer in vitro
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Description Original data of statistical graph in Figure 10
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Title Further confirmation of MBP-induced neurotoxicity
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Description Original data of statistical graph in Figure S1
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Title Neurotoxicity induced by heat-inactivated MBP
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Description Original data of statistical graph in Figure S2
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Title PRM induces neurotoxicity
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Description Original data of statistical graph in Figure S4
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Title MBP binds to sialic acid on neuronal surface
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Description Original data of statistical graph in Figure S5
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When using this data, please cite the original publication:

Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, Luo J (2014) Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane. PLoS ONE 9(9): e108646. http://dx.doi.org/10.1371/journal.pone.0108646

Additionally, please cite the Dryad data package:

Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, Luo J (2014) Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.211gr
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