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Data from: How to calculate the non­-synonymous to synonymous rate ratio of protein-coding genes under the Fisher­-Wright mutation­-selection framework

Cite this dataset

dos Reis, Mario (2015). Data from: How to calculate the non­-synonymous to synonymous rate ratio of protein-coding genes under the Fisher­-Wright mutation­-selection framework [Dataset]. Dryad. https://doi.org/10.5061/dryad.3r3q4

Abstract

First principles of population genetics are used to obtain formulae relating the non-synonymous to synonymous substitution rate ratio to the selection coefficients acting at codon sites in protein-coding genes. Two theoretical cases are discussed and two examples from real data (a chloroplast gene and a virus polymerase) are given. The formulae give much insight into the dynamics of non-synonymous substitutions and may inform the development of methods to detect adaptive evolution.

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