Data from: A simple biophysical model emulates budding yeast chromosome condensation

Cheng TMK, Heeger S, Chaleil RAG, Matthews N, Stewart A, Wright J, Lim C, Bates PA, Uhlmann F

Date Published: May 19, 2015

DOI: http://dx.doi.org/10.5061/dryad.78622

 

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Title Condensation of a single chromatin chain in the Type I model
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Description The movie shows the full length of simulated chromosome condensation. Nucleosomes are shown as grey spheres, condensin binding sites are in red. If more than two condensin binding sites come within 40 nm of each other, they are highlighted by a yellow sphere to indicate ‘rosette’ formation. Chromatin loops that connect condensin binding sites within rosettes are tinted cyan. A balanced co-existence of rosette and web-like structures in the compacted mitotic stage becomes apparent.
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Title Condensation of a single chromatin chain in the Type II model
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Description As previous movie, but the simulation followed the Type II model. Now the rosette-like topologies become dominant and the overall structure is densely packed.
Download single_chain_type_II.mp4 (183.7 Mb)
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Title Condensation of two nearby chromatin chains in the Type I model
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Description Full length movie of two chromatin chains compacting next to each other using the Type I model are shown, illustrating chain separation during condensation (chain 1, nucleosomes in light blue, condensin binding sties in red; chain 2, nucleosomes in yellow, condensin binding sites in green).
Download two_chains_type_I.mp4 (154.6 Mb)
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Title Condensation of two nearby chromatin chains in the Type II model
Downloaded 1 time
Description As previous movie, but using the Type II model. The two chromatin chains fail to separate during condensation.
Download two_chains_type_II.mp4 (140.3 Mb)
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When using this data, please cite the original publication:

Cheng TMK, Heeger S, Chaleil RAG, Matthews N, Stewart A, Wright J, Lim C, Bates PA, Uhlmann F (2015) A simple biophysical model emulates budding yeast chromosome condensation. eLife 4: e05565. http://dx.doi.org/10.7554/eLife.05565

Additionally, please cite the Dryad data package:

Cheng TMK, Heeger S, Chaleil RAG, Matthews N, Stewart A, Wright J, Lim C, Bates PA, Uhlmann F (2015) Data from: A simple biophysical model emulates budding yeast chromosome condensation. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.78622
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