Data from: Chemogenetic interrogation of a brain-wide fear memory network in mice

Vetere G, Kenney JW, Tran LM, Xia F, Steadman PE, Parkinson J, Josselyn SA, Frankland PW

Date Published: April 24, 2017

DOI: http://dx.doi.org/10.5061/dryad.86337

 

Files in this package

Content in the Dryad Digital Repository is offered "as is." By downloading files, you agree to the Dryad Terms of Service. To the extent possible under law, the authors have waived all copyright and related or neighboring rights to this data. CC0 (opens a new window) Open Data (opens a new window)

Title Figure_1A
Downloaded 17 times
Description All pair-wise correlations of Fos counts for the fear memory.
Download Figure_1A.csv (128.0 Kb)
Details View File Details
Title Figure_1B
Downloaded 11 times
Description Weighted adjacency matrix for the fear memory network.
Download Figure_1B.csv (22.09 Kb)
Details View File Details
Title Figure_1C
Downloaded 8 times
Description All pair-wise correlations of Fos counts from control animals.
Download Figure_1C.csv (130.5 Kb)
Details View File Details
Title Figure_1D
Downloaded 5 times
Description Weighted adjacency matrix for the control network.
Download Figure_1D.csv (16.52 Kb)
Details View File Details
Title Figure_2A
Downloaded 6 times
Description Weighted adjacency matrix following application of the disruption propagation model starting from node Re.
Download Figure_2A.csv (18.76 Kb)
Details View File Details
Title Figure_2B
Downloaded 6 times
Description Global efficiency before and after the application of the disruption propagation model to the fear memory network targeting node Re.
Download Figure_2B.csv (69 bytes)
Details View File Details
Title Figure_2C
Downloaded 7 times
Description The change in global efficiency following application of the disruption propagation model to each individual node, and the degree of each node, in the fear memory network.
Download Figure_2C.csv (2.11 Kb)
Details View File Details
Title Figure_3B
Downloaded 6 times
Description The effect of CNO administration on Fos expression in across different zeitgeber times.
Download Figure_3B.csv (922 bytes)
Details View File Details
Title Figure_3C
Downloaded 5 times
Description The effect of CNO administration on Fos expression in different brain regions.
Download Figure_3C.csv (479 bytes)
Details View File Details
Title Figure_3D
Downloaded 5 times
Description The effect of prolonged CNO administration on Fos expression.
Download Figure_3D.csv (141 bytes)
Details View File Details
Title Figure_5B
Downloaded 7 times
Description Percent freezing levels for mice expressing hM4Di in 21 different brain regions and administered CNO or VEH.
Download Figure_5B.csv (5.388 Kb)
Details View File Details
Title Figure_6ABD
Downloaded 6 times
Description Difference in freezing between CNO and VEH treated mice, changes in global efficiency for the fear memory and control networks following application of the disruption propagation model, and relative Fos levels.
Download Figure_6ABD.csv (771 bytes)
Details View File Details
Title Figure_6C
Downloaded 4 times
Description Difference in freezing between CNO and VEH treated mice, and the change in global efficiency following application of the disruption propagation model to the anatomical network.
Download Figure_6C.csv (541 bytes)
Details View File Details
Title Figure_S1ABC
Downloaded 7 times
Description Node degrees and clustering coefficients for the fear memory network.
Download Figure_S1ABC.csv (1.458 Kb)
Details View File Details
Title Figure_S1D
Downloaded 5 times
Description Node degrees for the control network.
Download Figure_S1D.csv (788 bytes)
Details View File Details
Title Figure_S1E
Downloaded 5 times
Description Weighted adjacency matrix for the anatomical network built using the same p-value as the fear memory network (p < 0.01).
Download Figure_S1E.csv (23.86 Kb)
Details View File Details
Title Figure_S1F
Downloaded 5 times
Description Weighted adjacency matrix for the anatomical network built to have the same density as the fear memory network.
Download Figure_S1F.csv (15.46 Kb)
Details View File Details
Title Figure_S1G
Downloaded 5 times
Description Node degrees for the anatomical network thresholded using the same p-value as the fear memory network (p < 0.01).
Download Figure_S1G.csv (746 bytes)
Details View File Details
Title Figure_S1H
Downloaded 6 times
Description Node degrees for the anatomical network thresholded to have the same density as the fear memory network.
Download Figure_S1H.csv (704 bytes)
Details View File Details
Title Figure_S1IJ
Downloaded 5 times
Description Node degrees in the fear memory and control networks.
Download Figure_S1IJ.csv (1.055 Kb)
Details View File Details
Title Figure_S1KL
Downloaded 8 times
Description Node degrees in the fear memory and anatomical networks.
Download Figure_S1KL.csv (994 bytes)
Details View File Details
Title Figure_S3AC
Downloaded 7 times
Description Shannon's entropy (H) for changes in the global efficiency and giant component size following application of the disruption propagation model to nodes of the fear memory network. The number of edge changes allowed during modeling was varied from 0 to 60.
Download Figure_S3AC.csv (2.451 Kb)
Details View File Details
Title Figure_S3BD
Downloaded 8 times
Description Shannon's entropy (H) for changes in the global efficiency and giant component size following application of the disruption propagation model to nodes of the fear memory network. The threshold applied following propagation was varied from 0 to 1.
Download Figure_S3BD.csv (4.019 Kb)
Details View File Details
Title Figure_S3E
Downloaded 4 times
Description Giant component size before and after the application of the disruption propagation model to the fear memory network targeting node Re.
Download Figure_S3E.csv (45 bytes)
Details View File Details
Title Figure_S3F
Downloaded 5 times
Description The change in giant component size following application of the disruption propagation model to each individual node, and the degree of each node, in the fear memory network.
Download Figure_S3F.csv (1.005 Kb)
Details View File Details
Title Figure_S4AB
Downloaded 5 times
Description The change in global efficiency and giant component size following either simple node deletion or the application of the disruption propagation model for each node in the fear memory network.
Download Figure_S4AB.csv (2.493 Kb)
Details View File Details
Title Figure_S4CD
Downloaded 8 times
Description Change in global efficiency and giant component size following simple node deletion, and node degrees, in the fear memory network.
Download Figure_S4CD.csv (2.362 Kb)
Details View File Details
Title Figure_S5A
Downloaded 6 times
Description Percent freezing in mice infused with a control virus and administered VEH or CNO.
Download Figure_S5A.csv (205 bytes)
Details View File Details
Title Figure_S5BCDEF
Downloaded 5 times
Description Difference in freezing between CNO and VEH treated animals. Changes in the giant component size for the fear memory network following application of the disruption propagation model. Node degrees in the fear memory network. Changes in the global efficiency of the fear memory network following simple node deletion. Alpha critical values derived from the cascading failure model applied to the fear memory network. Volume of each region targeted in behavioral experiments.
Download Figure_S5BCDEF.csv (869 bytes)
Details View File Details
Title Figure_S6A
Downloaded 5 times
Description Difference in freezing between CNO and VEH treated animals. Change in the global efficiency following application of the disruption propagation model to the control network with the same density as the fear memory network.
Download Figure_S6A.csv (509 bytes)
Details View File Details
Title Figure_S6B
Downloaded 8 times
Description Difference in freezing between CNO and VEH treated animals. Change in the global efficiency following application of the disruption propagation model to the anatomical network with the same density as the fear memory network.
Download Figure_S6B.csv (605 bytes)
Details View File Details
Title Cascading_failure_model
Downloaded 5 times
Description R implementation of the cascading failure model
Download Cascading_failure_model.R (6.795 Kb)
Details View File Details
Title Disruption_propagation_model
Downloaded 7 times
Description R implementation of the disruption propagation model
Download DPM.R (3.998 Kb)
Details View File Details

When using this data, please cite the original publication:

Vetere G, Kenney JW, Tran LM, Xia F, Steadman PE, Parkinson J, Josselyn SA, Frankland PW (2017) Chemogenetic interrogation of a brain-wide fear memory network in mice. Neuron 94(2): 363–374. http://dx.doi.org/10.1016/j.neuron.2017.03.037

Additionally, please cite the Dryad data package:

Vetere G, Kenney JW, Tran LM, Xia F, Steadman PE, Parkinson J, Josselyn SA, Frankland PW (2017) Data from: Chemogenetic interrogation of a brain-wide fear memory network in mice. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.86337
Cite | Share
Download the data package citation in the following formats:
   RIS (compatible with EndNote, Reference Manager, ProCite, RefWorks)
   BibTex (compatible with BibDesk, LaTeX)

Search for data

Be part of Dryad

We encourage organizations to: