Show simple item record Correia, Patrícia A. Lottem, Eran Banerjee, Dhruba Machado, Ana S. Carey, Megan R. Mainen, Zachary F.
dc.coverage.spatial Portugal 2017-02-17T22:37:54Z 2017-02-17T22:37:54Z 2017-02-14
dc.identifier doi:10.5061/dryad.bn1gf
dc.identifier.citation Correia PA, Lottem E, Banerjee D, Machado AS, Carey MR, Mainen ZF (2017) Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons. eLife 6: e20975.
dc.identifier.issn 2050-084X
dc.description Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset ≤1 s). Inhibition of locomotion was independent of measures of anxiety or motor impairment and could be overcome by strong motivational drive. Repetitive place-contingent pairing of activation caused neither place preference nor aversion. However, repeated 15 min daily stimulation caused a persistent increase in spontaneous locomotion to emerge over three weeks. These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions.
dc.relation.haspart doi:10.5061/dryad.bn1gf/1
dc.relation.isreferencedby doi:10.7554/eLife.20975
dc.subject serotonin
dc.subject dorsal raphe nucleus
dc.subject locomotion
dc.subject optogenetics
dc.subject mouse
dc.title Data from: Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
dc.type Article
dc.contributor.correspondingAuthor Correia, Patrícia A.
prism.publicationName eLife

Files in this package

Content in the Dryad Digital Repository is offered "as is." By downloading files, you agree to the Dryad Terms of Service. To the extent possible under law, the authors have waived all copyright and related or neighboring rights to this data. CC0 (opens a new window) Open Data (opens a new window)

Title Correia_etal2016_DATA
Downloaded 331 times
Description Correia_etal_DATA contains five experimental data sets: - open field experiment - open field long-term experiment - ROI experiment - rotarod experiment - locomouse experiment
Download README.docx (90.91 Kb)
Download (255.2 Mb)
Details View File Details

Search for data

Be part of Dryad

We encourage organizations to: