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dc.contributor.author Correia, Patrícia A.
dc.contributor.author Lottem, Eran
dc.contributor.author Banerjee, Dhruba
dc.contributor.author Machado, Ana S.
dc.contributor.author Carey, Megan R.
dc.contributor.author Mainen, Zachary F.
dc.coverage.spatial Portugal
dc.date.accessioned 2017-02-17T22:37:54Z
dc.date.available 2017-02-17T22:37:54Z
dc.date.issued 2017-02-14
dc.identifier doi:10.5061/dryad.bn1gf
dc.identifier.citation Correia PA, Lottem E, Banerjee D, Machado AS, Carey MR, Mainen ZF (2017) Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons. eLife 6: e20975.
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10255/dryad.125734
dc.description Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset ≤1 s). Inhibition of locomotion was independent of measures of anxiety or motor impairment and could be overcome by strong motivational drive. Repetitive place-contingent pairing of activation caused neither place preference nor aversion. However, repeated 15 min daily stimulation caused a persistent increase in spontaneous locomotion to emerge over three weeks. These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions.
dc.relation.haspart doi:10.5061/dryad.bn1gf/1
dc.relation.isreferencedby doi:10.7554/eLife.20975
dc.subject serotonin
dc.subject dorsal raphe nucleus
dc.subject locomotion
dc.subject optogenetics
dc.subject mouse
dc.title Data from: Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
dc.type Article
dc.contributor.correspondingAuthor Correia, Patrícia A.
prism.publicationName eLife

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