Data from: Formulation and toxicology evaluation of the intrathecal AYX1 DNA-decoy in Sprague Dawley rats

Mamet J, Yeomans DC, Yaksh T, Manning DC, Harris S

Date Published: May 26, 2017

DOI: http://dx.doi.org/10.5061/dryad.dh250

 

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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental protocol information
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Description Supplemental protocol information
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 1
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Description Stability of AYX1: calcium formulation with sodium phosphate or Tris buffers at 2 weeks
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 2
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Description Stability of the AYX1: calcium formulation with Tris buffer at 3 months
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 3
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Description Clinical laboratory assessments of female rats at Day 3 and 30 in the ADY-TX2 study
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 4
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Description ADY-TX2 study, Functional observation battery results, pre-dose and 4h post-dosing of Day 3 animals
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 5
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Description Histopathology analysis of lumbar spinal cord of female rats in the ADY-TX2 study
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 6
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Description Summary of Total AYX1 (full length + metabolites) toxicokinetics in the CSF and plasma of male and female rats in the ADY-TX2 study
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Tables 7abc
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Description Irwin Test, SNITX1 study
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Title Mamet et al, 2017 - Toxicological Sciences - 05 28 17 -Supplemental Table 8
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Description Clinical laboratory assessments at study Day 14 in the ADY-SNITX1 study
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Title Mamet et al, 2017 - Toxicological Sciences - 05 25 17 -Supplemental Table 9
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Description Histopathology evaluation at necropsy 14 days following dosing/SNI surgery, SNITX1 study
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When using this data, please cite the original publication:

Mamet J, Yeomans DC, Yaksh T, Manning DC, Harris S (2017) Formulation and toxicology evaluation of the intrathecal AYX1 DNA-decoy in Sprague Dawley rats. Toxicological Sciences, online in advance of print. http://dx.doi.org/10.1093/toxsci/kfx118

Additionally, please cite the Dryad data package:

Mamet J, Yeomans DC, Yaksh T, Manning DC, Harris S (2017) Data from: Formulation and toxicology evaluation of the intrathecal AYX1 DNA-decoy in Sprague Dawley rats. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.dh250
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