Data from: On the ancestral recruitment of metalloproteinases into the venom of snakes

Casewell, Nicholas R., Liverpool School of Tropical Medicine

Published Mar 13, 2012 on Dryad. https://doi.org/10.5061/dryad.fd5q0p68

Cite this dataset

Casewell, Nicholas R. (2012). Data from: On the ancestral recruitment of metalloproteinases into the venom of snakes [Dataset]. Dryad. https://doi.org/10.5061/dryad.fd5q0p68

Abstract

Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin 1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors elucidates progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

Usage notes

Casewell_metalloproteinase_alignment.fas

An amino acid sequence alignment of ADAM and ADAMTS proteins isolated from the genomes of Homo sapiens, Danio rerio and Anolis carolinensis with basal snake venom metalloproteinases isolated from Elapidae and Atractaspidinae