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dc.contributor.author Kato, Hiroki
dc.contributor.author Isohashi, Kayako
dc.contributor.author Shimosegawa, Eku
dc.contributor.author Hatazawa, Jun
dc.coverage.spatial Japan
dc.date.accessioned 2018-01-12T17:41:06Z
dc.date.available 2018-01-12T17:41:06Z
dc.date.issued 2018-01-11
dc.identifier doi:10.5061/dryad.hb149
dc.identifier.citation Kato H, Isohashi K, Shimosegawa E, Hatazawa J (2018) Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia. PLOS ONE 13(1): e0190720.
dc.identifier.uri http://hdl.handle.net/10255/dryad.156888
dc.description Background: Cerebral extraction of diffusively distributed substances like oxygen has been suggested to change according to the cerebral blood flow (CBF) and status of the microvasculature. The relationships between the cerebral extraction of diffusively distributed lipophilic tracers and the severity of cerebral ischemia has not yet been clarified. In the present study, we attempted to elucidate the association between the extraction fraction of the lipophilic tracer I-123 iomazenil (IMZ) (IMZ-EF) and the oxygen extraction fraction (OEF) derived from O-15 PET in patients with chronic steno-occlusive disease of internal carotid artery (ICA) or middle cerebral artery (MCA). Methods: Seven patients with unilateral chronic severe stenosis or occlusion of the middle cerebral/internal cerebral artery were prospectively recruited for this study. All the patients underwent both O-15 PET and quantitative I-123 IMZ SPECT. Parametric images derived from the PET and SPECT scans were anatomically normalized and evaluated by automated image analysis based on the volume-of-interest template. Results: The asymmetry index (AI) of IMZ-EF was shown to significantly correlated with the AI of OEF (r = 0.562, P < 0.001) in the internal carotid artery perfusion area. Strong and significant correlation between the AI of the influx rate constant K1 of IMZ and the AI of the cerebral metabolic rate of oxygen (r = 0.552, P = 0.001) was clarified. Conclusions: Our results suggested that the transportation efficiency of I-123 IMZ into the brain tissue was an indicator for evaluating severity of cerebral ischemia in patients with chronic steno-occlusive disease of ICA or MCA. Cerebral metabolic state can possibly be estimated by I-123 IMZ SPECT without cyclotron.
dc.relation.haspart doi:10.5061/dryad.hb149/1
dc.relation.haspart doi:10.5061/dryad.hb149/2
dc.relation.haspart doi:10.5061/dryad.hb149/3
dc.relation.haspart doi:10.5061/dryad.hb149/4
dc.relation.isreferencedby doi:10.1371/journal.pone.0190720
dc.subject SPECT
dc.subject PET
dc.subject Iomazenil
dc.subject cerebrovascular disease
dc.subject chronic cerebral hypoperfusion
dc.subject Oxygen Extraction Fraction
dc.subject cerebral blood flow
dc.subject Tracer Pharmacokinetics
dc.subject bloodbrain barrier
dc.subject Biological Transport
dc.title Data from: Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia
dc.type Article
prism.publicationName PLOS ONE

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Title Data for figure2
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Description The AI of the parameters in the 35 VOI pairs from the 7 patients
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Title Image data of figure3A
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Description Asymmetry maps of the patient with left ICA occlusion accompanied by old cerebral infarction in the left medial frontal lobe (Case 2 in Table 1); Image format is NIfTI. These images were overlayed on the template MRI.
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Title Image data of figure3B
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Description Asymmetry maps of the patient with near-occlusion of the left ICA (Case 5 in Table 1); Image format is NIfTI. These images were overlayed on the template MRI.
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Title PET and SPECT images
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Description PET and SPECT image data (NIfTI) of all the cases; early-SPECT: SPECT count image in the early phase scan, IMZ-K1: IMZ K1 parametric image (voxel value is 10000 times K1(ml/min)), PET-CBF: CBF parametric image (voxel value is 100 times CBF(ml/100ml/min), PET-CMRO2: CMRO2 parametric image (voxel value is 1000 times CMRO2(ml/100ml/min)), PET-OEF: OEF parametric image (voxel value is 100 times OEF(%).
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