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dc.contributor.author Wang, Guang-Yan
dc.contributor.author Zhu, Zhaoming
dc.contributor.author Cui, Shan
dc.contributor.author Wang, Jin-Hui
dc.date.accessioned 2017-08-11T22:27:02Z
dc.date.available 2017-08-11T22:27:02Z
dc.date.issued 2016-11-18
dc.identifier doi:10.5061/dryad.k9q7h
dc.identifier.citation Wang G, Zhu Z, Cui S, Wang J (2016) Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala. PLOS ONE 11(11): e0166535.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10255/dryad.127592
dc.description Background: Stressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. Methods and Results: Dexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. Conclusion: The upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
dc.relation.haspart doi:10.5061/dryad.k9q7h/1
dc.relation.haspart doi:10.5061/dryad.k9q7h/2
dc.relation.haspart doi:10.5061/dryad.k9q7h/3
dc.relation.haspart doi:10.5061/dryad.k9q7h/4
dc.relation.haspart doi:10.5061/dryad.k9q7h/5
dc.relation.haspart doi:10.5061/dryad.k9q7h/6
dc.relation.haspart doi:10.5061/dryad.k9q7h/7
dc.relation.haspart doi:10.5061/dryad.k9q7h/8
dc.relation.haspart doi:10.5061/dryad.k9q7h/9
dc.relation.haspart doi:10.5061/dryad.k9q7h/10
dc.relation.haspart doi:10.5061/dryad.k9q7h/11
dc.relation.haspart doi:10.5061/dryad.k9q7h/12
dc.relation.haspart doi:10.5061/dryad.k9q7h/13
dc.relation.haspart doi:10.5061/dryad.k9q7h/14
dc.relation.haspart doi:10.5061/dryad.k9q7h/15
dc.relation.haspart doi:10.5061/dryad.k9q7h/16
dc.relation.isreferencedby doi:10.1371/journal.pone.0166535
dc.subject stress
dc.subject dexamethasone
dc.subject GABA
dc.subject glutamate
dc.subject neuron
dc.subject synapse
dc.subject amygdala
dc.subject Neuroscience
dc.title Data from: Glucocorticoid induces incoordination between glutamatergic and GABAergic neurons in the amygdala
dc.type Article
prism.publicationName PLOS ONE

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Title 40 mg/kg DEX injection-sEPSC Ctrl.12 Inj.19
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Description This excel includes all original data related to sEPSC recorded on GABAergic neurons from 40 mg/kg DEX injection and saline injection mice.
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Title 40 mg/kg DEX injection-sIPSC Ctrl.13 Inj.11
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Description This excel includes all available original data related to sIPSC recorded on glutamatergic neurons in in the mouse amygdala, in which the mice were treated by the intraperitoneal injections of dexamethasone (DEX,40 mg/kg) once a day or for one week.There are 13 cells in control group and 11 cells in the DEX injection group.
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Title ISI(40 mg/kg DEX injection-GABAergic neurons) Ctrl.11 Inj.11
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Description This excel includes all available original data related to the intervals of spikes(ISI) recorded on GABAergic neurons in DEX injection mice(n=11 cells) and in saline injection mice(n=11 cells)
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Title ISI(40 mg/kg DEX injection-Gluergic neurons) Ctrl.19 Inj.28
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Description This excel includes original data related to the inter-spike intervals(ISI) recorded on Gluergic neurons in DEX injection (n=28 cells) and saline injection(n=19 cells).
Download ISI(injection-PN) Ctrl.19 Inj.28.xlsx (111.1 Kb)
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Title 25 uM DEX washing-on sEPSC n=14cells
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Description This excel includes original data related to the inter-spike intervals(ISI) recorded on GABAergic neurons(n=14) before and after DEX washing on.
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Title 25 uM DEX washing-on IPSC n=10cells
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Description This excel includes original data related to the inter-spike intervals(ISI) recorded on Gluergic neurons(n=10) before and after DEX washing on.
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Title ISI(25 uM DEX washing-on-GABAergic neurons)13Cells
Downloaded 3 times
Description This excel includes original data related to the inter-spike intervals(ISI) recorded on GABAergic neurons(n=13) before and after DEX washing on.
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Title ISI (25 uM DEX washing-on-Gluergic neurons) 14cells
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Description This excel includes original data related to the inter-spike intervals recorded on Gluergic neurons(n=14) before and after DEX washing on.
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Title 40 mg/kg DEX injectioin-sEPSC Ctrl.12 Inj.19
Downloaded 2 times
Description This is an opj. file which can be opened by origin software.It includes data related to sIPSC on Gluergic neurons from DEX injection and saline injection mice and data processing. Moreover,origin software is used to analyse all data related to our exprements.
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Title 40 mg/kg DEX injection-sIPSC Ctrl.13 Inj.11
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Description This is an opj. file which can be opened by origin software.It includes data related to sIPSC on Gluergic neurons from DEX injection and saline injection mice and data processing.
Download 40 mg per kg DEX injection-sIPSC Ctrl.13 ...11.opj (18.72 Mb)
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Title ISI(40 mg/kg DEX injection-GABAergic neuron) Ctrl.11 Inj.11
Downloaded 2 times
Description An opj.file including data related to inter-spike intervals on GABAergic neurons from DEX injection and saline injection mice and data processing.
Download ISI(DEX injection-GABAergic neuron) Ctrl....11.opj (528.0 Kb)
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Title ISI(40 mg/kg DEX injection-Gluergic neuron) Ctrl.19 Inj. 28
Downloaded 2 times
Description An opj.file including data related to the inter-spike intervals on Gluergic neurons from DEX injection and saline injection and data processing.
Download ISI(DEX injection-Gluergic neuron ) Ctrl....28.opj (540.0 Kb)
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Title 25 uM DEX washing-on sEPSC 14cells
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Description An opj. file including data related to sEPSC on GABAergic neurons before and after DEX washing on and data processing.
Download 25 uM washing-on sEPSC 14cells.opj (22.01 Mb)
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Title 25 uM DEX washing-on-sIPSC 10cells
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Description An opj. file including data related to sIPSC on Gluergic neurons before and after DEX washing on and data processing.
Download 25 uM washing-on-IPSC 10cells.opj (15.91 Mb)
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Title ISI(25 uM DEX washing-on-GABAergic neuron)13Cells
Downloaded 2 times
Description An opj. file including data related to inter-spike intervals(ISI) on GABAergic neurons before and after DEX washing on and data processing.
Download ISI(25 uM DEX washing-on-GABAergic neuron...ls.opj (523.0 Kb)
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Title ISI(25 uM DEX washing-on-Gluergic neuron)14Cells
Downloaded 2 times
Description An opj. file including data related to inter-spike intervals on Gluergic neurons before and after DEX washing on and data processing.
Download ISI(25 uM DEX washing-on-Gluergic neuron)...ls.opj (520.0 Kb)
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