Data from: Assessment of dysmyelination with RAFFn MRI: application to murine MPS I

Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S, Parr AM, Low WC

Date Published: February 23, 2015

DOI: http://dx.doi.org/10.5061/dryad.ng64q

 

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Title Histology images
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Description Zipped folder containing photomicrographs of mouse brain sections. Sections are from MPS I mice and IDUA heterozygotes, and are stained with the black gold stain. Images have been resized and converted to grayscale. Images are scaled to 173 pixels per millimeter unless noted otherwise in the filename (“..._NotToScale”). Files are titled "histology_[mouse identifier]_[tissue section identifier].tif". Mice 13021, 13224, 13255, N3, N4, and N5 are mice with MPS I; mice 13257, 13258, N1, N2, and N6 are heterozygotes.
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Title Histology analysis_for Dryad
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Description Excel spreadsheet containing analyzed histological data. The “Optical density” tab contains raw optical density values for each tissue section, normalized values, normalized means for each animal, and normalized means for each genotype. The “Outliers” tab contains analysis of each animal for outlying values (see the publication in PLOS ONE for details). The “cc thickness” tab contains raw data for corpus callosum thickness, comparison with atlas values for each section, animal means, and genotype means. Mice 13021, 13224, 13255, N3, N4, and N5 are mice with MPS I; mice 13257, 13258, N1, N2, and N6 are heterozygotes.
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Title MRI relaxation time constant maps
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Description Zipped folder containing MRI relaxation time constant maps. Files are meant to be opened and analyzed using the Aedes toolbox for MATLAB. See the publication in PLOS ONE for more details. Files are titled "MRI _[mouse identifier]_[MRI sequence].t1r [or .t1]". Mice 13021, 13224, 13255, N3, N4, and N5 are mice with MPS I; mice 13257, 13258, N1, N2, and N6 are heterozygotes.
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Title MRI analysis_for Dryad
Downloaded 11 times
Description Excel spreadsheet containing analyzed MRI data. The “MRI ROI comparison” tab contains mean relaxation time constants for each ROI in each animal for each sequence, as well as means for each genotype. The “MRI vs histology” tab contains correlation of tissue section-derived normalized optical density with MRI relaxation time constants for each MRI sequence. The “Outliers” tab contains analysis of each animal for outlying values (see the publication in PLOS ONE for details). Mice 13021, 13224, 13255, N3, N4, and N5 are mice with MPS I; mice 13257, 13258, N1, N2, and N6 are heterozygotes.
Download MRI analysis_for Dryad.xlsx (113.2 Kb)
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When using this data, please cite the original publication:

Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S, Parr AM, Low WC (2015) Assessment of dysmyelination with RAFFn MRI: application to murine MPS I. PLoS ONE 10(2): e0116788. http://dx.doi.org/10.1371/journal.pone.0116788

Additionally, please cite the Dryad data package:

Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S, Parr AM, Low WC (2015) Data from: Assessment of dysmyelination with RAFFn MRI: application to murine MPS I. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.ng64q
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