Data from: Generalized selection to overcome innate immunity selects for host breadth in an RNA virus

Wasik BR, Muñoz-Rojas AR, Okamoto KW, Miller-Jensen K, Turner PE

Date Published: December 16, 2015

DOI: http://dx.doi.org/10.5061/dryad.p9q57

 

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Title Figure 2. B) Measurements of IFN-β gene induction in HeLa and MDCK cells via qPCR
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Description This is the data corresponding to figure 2B, which describes the relative transcript levels of IFBN-beta in MDCK and HeLa cells after infection with VSV M51R.
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Title Fig 3. A-C) Quantification of IFN response in PC-3 and LNCaP cells
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Description This file includes the data for Figure 3 A-C. Fig. 3A includes the data for IFN-b secretion by PC3 and LnCap cells after VSV infection, as measured by ELISA. Figure 3B-C) has the normalized transcript quantities for MXA and OAS1 after stimulation with IFN-b, as measured by RT-qPCR.
Download Fig3A-C_IFNbresponse.xlsx (47.43 Kb)
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Title Figure 5. Selection in temporally heterogeneous innate immune environments leads to VSV strains with differential capacities to block IFN-β production.
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Description This data corresponds to the graph in Figure 5. It describes the secretion of IFN-b in PC3 cells (as measured by ELISA) after infection with different strains of VSV experimentally evolved in heterogeneous innate immune environments.
Download Fig5_AltPop.xlsx (39.84 Kb)
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When using this data, please cite the original publication:

Wasik BR, Muñoz-Rojas AR, Okamoto KW, Miller-Jensen K, Turner PE (2016) Generalized selection to overcome innate immunity selects for host breadth in an RNA virus. Evolution 70(2): 270–281. http://dx.doi.org/10.1111/evo.12845

Additionally, please cite the Dryad data package:

Wasik BR, Muñoz-Rojas AR, Okamoto KW, Miller-Jensen K, Turner PE (2016) Data from: Generalized selection to overcome innate immunity selects for host breadth in an RNA virus. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.p9q57
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