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dc.contributor.author Lahti, Leo
dc.contributor.author Salojärvi, Jarkko
dc.contributor.author Salonen, Anne
dc.contributor.author Scheffer, Marten
dc.contributor.author de Vos, Willem M.
dc.coverage.spatial Europe
dc.coverage.spatial Northern Europe
dc.coverage.spatial Southern Europe
dc.coverage.spatial Eastern Europe
dc.coverage.spatial Central Europe
dc.coverage.spatial Nordic countries
dc.coverage.spatial United States
dc.coverage.spatial United Kingdom
dc.coverage.spatial Ireland
dc.date.accessioned 2014-07-10T12:19:31Z
dc.date.available 2014-07-10T12:19:31Z
dc.date.issued 2014-07-09
dc.identifier doi:10.5061/dryad.pk75d
dc.identifier.citation Lahti L, Salojärvi J, Salonen A, Scheffer M, de Vos WM (2014) Tipping elements in the human intestinal ecosystem. Nature Communications 5: 4344.
dc.identifier.uri http://hdl.handle.net/10255/dryad.64664
dc.description The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify groups of bacteria that exhibit robust bistable abundance distributions. These bacteria are either abundant or nearly absent in most individuals, and exhibit decreased temporal stability at the intermediate abundance range. The abundances of these bimodally distributed bacteria vary independently, and their abundance distributions are not affected by short-term dietary interventions. However, their contrasting alternative states are associated with host factors such as ageing and overweight. We propose that the bistable groups reflect tipping elements of the intestinal microbiota, whose critical transitions may have profound health implications and diagnostic potential.
dc.relation.haspart doi:10.5061/dryad.pk75d/1
dc.relation.haspart doi:10.5061/dryad.pk75d/2
dc.relation.isreferencedby doi:10.1038/ncomms5344
dc.relation.isreferencedby PMID:25003530
dc.subject gut
dc.subject microbiota
dc.subject human
dc.subject alternative stable states
dc.subject tipping element
dc.subject critical transitions
dc.subject bi-stability
dc.title Data from: Tipping elements in the human intestinal ecosystem
dc.type Article
dwc.ScientificName Dialister spp.
dwc.ScientificName Bacteroides fragilis
dwc.ScientificName Uncultured Clostridiales
dwc.ScientificName Prevotella
dwc.ScientificName Prevotella oralis
dwc.ScientificName Prevotella melaninogenica
dwc.ScientificName Clostridium difficile
dwc.ScientificName Uncultured Mollicutes
dwc.ScientificName Lactobacillus plantarum
dwc.ScientificName Clostridium
dwc.ScientificName Clostridium colinum
prism.publicationName Nature Communications

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Title HITChip phylogenetic microarray data matrix
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Description Profiling of 130 genus-like taxa across 1006 western subjects based on the Human Intestinal Tract (HIT)Chip phylogenetic microarray.
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Title Metadata
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Description Metadata for the 1172 samples in the HITChip data matrix including age, sex, geographic region, DNA extraction information, projectID, probe-level Shannon diversity, BMI group,subjectID and time point. For units and other details, see the README file.
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