Data from: Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

Huh CJ, Zhang B, Victor M, Dahiya S, Batista LFZ, Horvath S, Yoo AS

Date Published: September 23, 2016

DOI: http://dx.doi.org/10.5061/dryad.t6096

 

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Title Datasets_Transcriptome_And_microRNAome
Downloaded 12 times
Description Compressed datasets for Agilent_Human4X44K_v1 microarray transcriptome and Affymetrix miRNA V4 microarray microRNAome data. When unzipped, three folders will appear: Raw_Data, Processed_data and DEGs. Raw_Data folder contains raw datasets for Agilent and Affy chips. Processed_data folder contains Agilent and Affy datasets processed for downstream differentially expressed genes (DEG) analyses. DEGs folder contains mRNA (transcriptome) and miRNA (microRNAome) sub-directories containing DEG analyses for mRNAs and microRNAs.
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Title GO terms described in Figure 3- Figure Supplement 1-2
Downloaded 8 times
Description Full list of gene ontology terms and corresponding genes from figure 3 supplement 1 and figure 3 supplement 2. Includes GO terms for age-downregulated genes in reprogrammed neurons (sheet 1), GO terms for age-upregulated genes in reprogrammed neurons (sheet 2), GO terms for predicted targets of miR-497-5p from list of downregulated genes (sheet 3), GO terms for predicted targets of miR-10a from the list of downregulated genes (sheet 4)
Download GO terms.xlsx (41.32 Kb)
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Title Zipped folder of DNA methylation data and annotation
Downloaded 17 times
Description This zipped package contains 4 files.• The file dat0NoobUpload.csv contains the "Noob" normalized beta values (i.e. the DNA methylation data) from the Illumina 450K array platform. We used the Noob normalization described in TJ Triche et al (2013) Nucleic Acids Res 41, e90. • The sample annotation file (datSampleNoobUpload.csv) reports the chronological age (Age) and the DNA methylation age (DNAmAge) which was calculated with the epigenetic clock method described in Horvath S (2013) Genome Biol. 2013 • The file datPairedData.csv reports the DNAm age estimates before and after conversion.
Download DNAmethylation.zip (214.8 Mb)
Download README.docx (14.00 Kb)
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When using this data, please cite the original publication:

Huh CJ, Zhang B, Victor M, Dahiya S, Batista LFZ, Horvath S, Yoo AS (2016) Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. eLife 5: e18648. http://dx.doi.org/10.7554/elife.18648

Additionally, please cite the Dryad data package:

Huh CJ, Zhang B, Victor M, Dahiya S, Batista LFZ, Horvath S, Yoo AS (2016) Data from: Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.t6096
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