{"_links":{"self":{"href":"/api/v2/datasets/doi%3A10.5061%2Fdryad.58791"},"stash:versions":{"href":"/api/v2/datasets/doi%3A10.5061%2Fdryad.58791/versions"},"stash:version":{"href":"/api/v2/versions/13516"},"stash:download":{"href":"/api/v2/datasets/doi%3A10.5061%2Fdryad.58791/download"},"curies":[{"name":"stash","href":"https://github.com/datadryad/dryad-app/blob/main/documentation/apis/link_relations.md#{rel}","templated":"true"}]},"identifier":"doi:10.5061/dryad.58791","id":13464,"storageSize":54983,"relatedPublicationISSN":"1932-6203","title":"Data from: Retinal capillary rarefaction in patients with type 2 diabetes mellitus","authors":[{"firstName":"Agnes","lastName":"Jumar","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"}]},{"firstName":"Joanna M.","lastName":"Harazny","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"},{"name":"University of Warmia and Mazury in Olsztyn","ror_id":"https://ror.org/05s4feg49"}]},{"firstName":"Christian","lastName":"Ott","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"}]},{"firstName":"Stefanie","lastName":"Friedrich","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"}]},{"firstName":"Iris","lastName":"Kistner","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"}]},{"firstName":"Kristina","lastName":"Striepe","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"}]},{"firstName":"Roland","lastName":"Schmieder"},{"firstName":"Roland E.","lastName":"Schmieder","affiliation":"Friedrich-Alexander-Universität Erlangen-Nürnberg","affiliationROR":"https://ror.org/00f7hpc57","affiliations":[{"name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","ror_id":"https://ror.org/00f7hpc57"}]}],"abstract":"Purpose: In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.  Methods: This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and capillary area (CapA), measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2.  Results: In diabetic patients, ICD was greater (23.2±5.5 vs 20.2±4.2, p = 0.013) and CapA smaller (1592±595 vs 1821±652, p = 0.019) than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD (23.1±5.8, p = 0.781) and CapA (1556±649, p = 0.768).  Conclusion: In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals.","keywords":["capillary rarefaction","diabetes","Hypertension","end-organ damage"],"usageNotes":"\u003cdiv class=\"o-metadata__file-usage-entry\"\u003e\u003ch4 class=\"o-heading__level3-file-title\"\u003ePlosOne_beb\u003c/h4\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003c/div\u003e","relatedWorks":[{"relationship":"primary_article","identifierType":"DOI","identifier":"https://doi.org/10.1371/journal.pone.0162608"}],"versionNumber":1,"versionStatus":"submitted","curationStatus":"Published","versionChanges":"none","publicationDate":"2017-11-15","lastModificationDate":"2020-06-24","visibility":"public","sharingLink":"http://datadryad.org/dataset/doi:10.5061/dryad.58791","changedFields":["none"],"license":"https://spdx.org/licenses/CC0-1.0.html","metrics":{"views":641,"downloads":107,"citations":1}}