{"_links":{"self":{"href":"/api/v2/datasets/doi:10.5061%2Fdryad.97r9289/versions"},"first":{"href":"/api/v2/datasets/doi:10.5061%2Fdryad.97r9289/versions"},"last":{"href":"/api/v2/datasets/doi:10.5061%2Fdryad.97r9289/versions?page=1"}},"count":3,"total":3,"_embedded":{"stash:versions":[{"_links":{"self":{"href":"/api/v2/versions/22957"},"stash:dataset":{"href":"/api/v2/datasets/doi%3A10.5061%2Fdryad.97r9289"},"stash:files":{"href":"/api/v2/versions/22957/files"},"stash:download":{"href":"/api/v2/versions/22957/download"},"curies":[{"name":"stash","href":"https://github.com/datadryad/dryad-app/blob/main/documentation/apis/link_relations.md#{rel}","templated":"true"}]},"title":"Data from: One and two year visual outcomes from the Moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource","authors":[{"firstName":"Katrin","lastName":"Fasler","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Gabriella","lastName":"Moraes","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Siegfried K.","lastName":"Wagner","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Karsten U.","lastName":"Kortuem","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Reena","lastName":"Chopra","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Livia","lastName":"Faes","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Gabriella","lastName":"Preston","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Nikolas","lastName":"Pontikos","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Dun Jack","lastName":"Fu","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Praveen J.","lastName":"Patel","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Adnan","lastName":"Tufail","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Aaron Y.","lastName":"Lee","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Konstantinos","lastName":"Balaskas","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null},{"firstName":"Pearse A.","lastName":"Keane","email":null,"affiliation":null,"affiliationROR":null,"affiliations":[],"orcid":null,"order":null}],"abstract":"Objectives: To analyse treatment outcomes and share clinical data from a large, single-center, well-curated database (8174 eyes / 6664 patients with 120,756 single entries) of patients with neovascular age related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF). By making our depersonalised raw data openly available, we aim to stimulate further research in AMD, as well as setting a precedent for future work in this area.\r\nSetting: Retrospective, comparative, non-randomised electronic medical record (EMR) database cohort study of the UK Moorfields AMD database with data extracted between 2008 and 2018.\r\nParticipants:\tIncluding one eye per patient, 3357 eyes/patients (61% female). Extraction criteria were ≥ 1 ranibizumab or aflibercept injection, entry of “AMD” in the diagnosis field of the EMR, and a minimum of one year of follow-up. Exclusion criteria were unknown date of first injection and treatment outside of routine clinical care at Moorfields before the first recorded injection in the database.\r\nMain outcome measures: Primary outcome measure was change in VA at one and two years from baseline as measured in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Secondary outcomes were the number of injections and predictive factors for VA gain.\r\nResults: Mean VA gain at one-year and two years were +5.5 (95%CI:5.0,6.0) and +4.9 (95%CI:4.2,5.6) letters respectively. Fifty-four percent of eyes gained ≥5 letters at two years, 63% had stable VA (±≤14 letters), forty-four percent of eyes maintained good VA (≥70 letters). Patients received a mean of 7.7 (95%CI:7.6,7.8) injections during year one and 13.0 (95%CI:12.8,13.2) injections over two years. Younger age, lower baseline VA, and more injections were associated with higher VA gain at two years.\r\nConclusion: This study benchmarks high quality EMR study results of real life AMD treatment and promotes open science in clinical AMD research by making the underlying data publicly available.","keywords":["choroidal neovascularization","Visual outcome","Age-related macular degeneration","aflibercept","anti-VEGF","ranibizumab","Electronic medical record"],"usageNotes":"\u003cdiv class=\"o-metadata__file-usage-entry\"\u003e\u003ch4 class=\"o-heading__level3-file-title\"\u003eMoorfields_AMD_Database_1\u003c/h4\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003c/div\u003e","locations":[{"place":"United Kingdom"}],"relatedWorks":[{"relationship":"primary_article","identifierType":"DOI","identifier":"https://doi.org/10.1136/bmjopen-2018-027441"}],"versionNumber":1,"versionStatus":"submitted","curationStatus":"Published","versionChanges":"none","publicationDate":"2019-05-22","lastModificationDate":"2019-07-15","visibility":"public","sharingLink":"http://datadryad.org/dataset/doi:10.5061/dryad.97r9289"},{"_links":{"self":{"href":"/api/v2/versions/62088"},"stash:dataset":{"href":"/api/v2/datasets/doi%3A10.5061%2Fdryad.97r9289"},"stash:files":{"href":"/api/v2/versions/62088/files"},"stash:download":{"href":"/api/v2/versions/62088/download"},"curies":[{"name":"stash","href":"https://github.com/datadryad/dryad-app/blob/main/documentation/apis/link_relations.md#{rel}","templated":"true"}]},"title":"Data from: One and two year visual outcomes from the Moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource","authors":[{"firstName":"Katrin","lastName":"Fasler","email":"katrin.fasler@usz.ch","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":"0000-0002-0348-961X","order":null},{"firstName":"Gabriella","lastName":"Moraes","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Siegfried K.","lastName":"Wagner","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Karsten U.","lastName":"Kortuem","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Reena","lastName":"Chopra","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Livia","lastName":"Faes","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Gabriella","lastName":"Preston","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Nikolas","lastName":"Pontikos","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Dun Jack","lastName":"Fu","email":"","affiliation":"UCL Biomedical Research Centre","affiliationROR":"https://ror.org/03r9qc142","affiliations":[{"name":"UCL Biomedical Research Centre","ror_id":"https://ror.org/03r9qc142"}],"orcid":null,"order":null},{"firstName":"Praveen J.","lastName":"Patel","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Adnan","lastName":"Tufail","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Aaron Y.","lastName":"Lee","email":"","affiliation":"University of Washington","affiliationROR":"https://ror.org/00cvxb145","affiliations":[{"name":"University of Washington","ror_id":"https://ror.org/00cvxb145"}],"orcid":null,"order":null},{"firstName":"Konstantinos","lastName":"Balaskas","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Pearse A.","lastName":"Keane","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null}],"abstract":"Objectives: To analyse treatment outcomes and share clinical data from a large, single-center, well-curated database (8174 eyes / 6664 patients with 120,756 single entries) of patients with neovascular age related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF). By making our depersonalised raw data openly available, we aim to stimulate further research in AMD, as well as setting a precedent for future work in this area.\r\nSetting: Retrospective, comparative, non-randomised electronic medical record (EMR) database cohort study of the UK Moorfields AMD database with data extracted between 2008 and 2018.\r\nParticipants:\tIncluding one eye per patient, 3357 eyes/patients (61% female). Extraction criteria were ≥ 1 ranibizumab or aflibercept injection, entry of “AMD” in the diagnosis field of the EMR, and a minimum of one year of follow-up. Exclusion criteria were unknown date of first injection and treatment outside of routine clinical care at Moorfields before the first recorded injection in the database.\r\nMain outcome measures: Primary outcome measure was change in VA at one and two years from baseline as measured in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Secondary outcomes were the number of injections and predictive factors for VA gain.\r\nResults: Mean VA gain at one-year and two years were +5.5 (95%CI:5.0,6.0) and +4.9 (95%CI:4.2,5.6) letters respectively. Fifty-four percent of eyes gained ≥5 letters at two years, 63% had stable VA (±≤14 letters), forty-four percent of eyes maintained good VA (≥70 letters). Patients received a mean of 7.7 (95%CI:7.6,7.8) injections during year one and 13.0 (95%CI:12.8,13.2) injections over two years. Younger age, lower baseline VA, and more injections were associated with higher VA gain at two years.\r\nConclusion: This study benchmarks high quality EMR study results of real life AMD treatment and promotes open science in clinical AMD research by making the underlying data publicly available.","keywords":["choroidal neovascularization","Visual outcome","Age-related macular degeneration","aflibercept","anti-VEGF","ranibizumab","Electronic medical record"],"usageNotes":"\u003cdiv class=\"o-metadata__file-usage-entry\"\u003e\u003ch4 class=\"o-heading__level3-file-title\"\u003eMoorfields_AMD_Database_1\u003c/h4\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003c/div\u003e","locations":[{"place":"United Kingdom"}],"relatedWorks":[{"relationship":"primary_article","identifierType":"DOI","identifier":"https://doi.org/10.1136/bmjopen-2018-027441"}],"versionNumber":3,"versionStatus":"submitted","curationStatus":"Published","versionChanges":"metadata_changed","publicationDate":"2020-04-21","lastModificationDate":"2020-04-21","visibility":"public","sharingLink":"http://datadryad.org/dataset/doi:10.5061/dryad.97r9289"},{"_links":{"self":{"href":"/api/v2/versions/69212"},"stash:dataset":{"href":"/api/v2/datasets/doi%3A10.5061%2Fdryad.97r9289"},"stash:files":{"href":"/api/v2/versions/69212/files"},"stash:download":{"href":"/api/v2/versions/69212/download"},"curies":[{"name":"stash","href":"https://github.com/datadryad/dryad-app/blob/main/documentation/apis/link_relations.md#{rel}","templated":"true"}]},"title":"Data from: One and two year visual outcomes from the Moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource","authors":[{"firstName":"Katrin","lastName":"Fasler","email":"katrin.fasler@usz.ch","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":"0000-0002-0348-961X","order":null},{"firstName":"Gabriella","lastName":"Moraes","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Siegfried K.","lastName":"Wagner","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Karsten U.","lastName":"Kortuem","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Reena","lastName":"Chopra","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Livia","lastName":"Faes","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Gabriella","lastName":"Preston","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Nikolas","lastName":"Pontikos","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Dun Jack","lastName":"Fu","email":"","affiliation":"UCL Biomedical Research Centre","affiliationROR":"https://ror.org/03r9qc142","affiliations":[{"name":"UCL Biomedical Research Centre","ror_id":"https://ror.org/03r9qc142"}],"orcid":null,"order":null},{"firstName":"Praveen J.","lastName":"Patel","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Adnan","lastName":"Tufail","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Aaron Y.","lastName":"Lee","email":"","affiliation":"University of Washington","affiliationROR":"https://ror.org/00cvxb145","affiliations":[{"name":"University of Washington","ror_id":"https://ror.org/00cvxb145"}],"orcid":null,"order":null},{"firstName":"Konstantinos","lastName":"Balaskas","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null},{"firstName":"Pearse A.","lastName":"Keane","email":"","affiliation":"Moorfields Eye Hospital NHS Foundation Trust","affiliationROR":"https://ror.org/03zaddr67","affiliations":[{"name":"Moorfields Eye Hospital NHS Foundation Trust","ror_id":"https://ror.org/03zaddr67"}],"orcid":null,"order":null}],"abstract":"Objectives: To analyse treatment outcomes and share clinical data from a large, single-center, well-curated database (8174 eyes / 6664 patients with 120,756 single entries) of patients with neovascular age related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF). By making our depersonalised raw data openly available, we aim to stimulate further research in AMD, as well as setting a precedent for future work in this area.\r\nSetting: Retrospective, comparative, non-randomised electronic medical record (EMR) database cohort study of the UK Moorfields AMD database with data extracted between 2008 and 2018.\r\nParticipants:\tIncluding one eye per patient, 3357 eyes/patients (61% female). Extraction criteria were ≥ 1 ranibizumab or aflibercept injection, entry of “AMD” in the diagnosis field of the EMR, and a minimum of one year of follow-up. Exclusion criteria were unknown date of first injection and treatment outside of routine clinical care at Moorfields before the first recorded injection in the database.\r\nMain outcome measures: Primary outcome measure was change in VA at one and two years from baseline as measured in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Secondary outcomes were the number of injections and predictive factors for VA gain.\r\nResults: Mean VA gain at one-year and two years were +5.5 (95%CI:5.0,6.0) and +4.9 (95%CI:4.2,5.6) letters respectively. Fifty-four percent of eyes gained ≥5 letters at two years, 63% had stable VA (±≤14 letters), forty-four percent of eyes maintained good VA (≥70 letters). Patients received a mean of 7.7 (95%CI:7.6,7.8) injections during year one and 13.0 (95%CI:12.8,13.2) injections over two years. Younger age, lower baseline VA, and more injections were associated with higher VA gain at two years.\r\nConclusion: This study benchmarks high quality EMR study results of real life AMD treatment and promotes open science in clinical AMD research by making the underlying data publicly available.","keywords":["choroidal neovascularization","Visual outcome","Age-related macular degeneration","aflibercept","anti-VEGF","ranibizumab","Electronic medical record"],"usageNotes":"\u003cdiv class=\"o-metadata__file-usage-entry\"\u003e\u003ch4 class=\"o-heading__level3-file-title\"\u003eMoorfields_AMD_Database_1\u003c/h4\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003cdiv class=\"o-metadata__file-name\"\u003e\u003c/div\u003e\u003c/div\u003e","locations":[{"place":"United Kingdom"}],"relatedWorks":[{"relationship":"primary_article","identifierType":"DOI","identifier":"https://doi.org/10.1136/bmjopen-2018-027441"}],"versionNumber":4,"versionStatus":"submitted","curationStatus":"Published","versionChanges":"files_changed","publicationDate":"2020-07-29","lastModificationDate":"2020-07-29","visibility":"public","sharingLink":"http://datadryad.org/dataset/doi:10.5061/dryad.97r9289"}]}}