Data from: Bursts of amino acid replacements in protein evolution
Data files
Feb 26, 2019 version files 1.73 MB
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acantho.nwk
477 B
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cog05361_NOP16.fasta
15.06 KB
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cog05414_DNAJC11.fasta
27.20 KB
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cog05812_MRPL22.fasta
11.84 KB
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cog06250_AKR1.fasta
23.46 KB
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cog06257_MRPS25.fasta
16.55 KB
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eulimno.nwk
1.21 KB
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hyall.nwk
274 B
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micro.nwk
421 B
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pallasea.nwk
788 B
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PKR.fasta
18.44 KB
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sn_Acantho.out
385.13 KB
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sn_Eulimno.out
464.19 KB
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sn_Hyall.out
199.16 KB
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sn_Micro.out
97.61 KB
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sn_Pallasea.out
465.38 KB
Abstract
Evolution can occur both gradually and through alternating episodes of stasis and rapid changes. However, the prevalence and magnitude of fluctuations of the rate of evolution remains obscure. Detecting a rapid burst of changes requires a detailed record of past evolution, so that events that occurred within a short time interval can be identified. Here, we use the phylogenies of the Baikal Lake amphipods and of Catarrhini, which contain very short internal edges facilitating this task. We detect 6 radical bursts of evolution of individual proteins during such short time periods, each involving between 6 and 38 amino acid substitutions. These bursts were extremely unlikely to have occurred neutrally, and were apparently caused by positive selection. On average, in the course of a time interval required for one synonymous substitution per site, a protein undergoes a strong burst of rapid evolution with probability at least ~0.01.