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Dryad

Data and code from: Impact of dosing schedules on performance of rotavirus vaccines in Ghana

Data files

Oct 14, 2024 version files 35.24 KB

Abstract

There is currently limited evidence regarding how the rotavirus vaccine dosing schedule might be adjusted to improve vaccine performance. We quantified and compared the impact of the previously implemented 6/10-week monovalent Rotarix vaccine in Ghana to the model-predicted impact for other vaccine dosing schedules across three hospitals and the entire country. Compared to no vaccination, the model-estimated median percentage reductions in rotavirus ranged from 28-85% and 12-71% among children <1 year and <5 years of age, respectively. The median predicted reductions in rotavirus for the whole country ranged from 57-66% among infants <1 year and 35-45% among children <5 years of age. The 1/6/10- and 6/10/14-week schedules provided the best and comparable reductions in rotavirus compared to the original 6/10-week schedule, whereas there was no improvement in impact for the 10/14-week schedule. A third dose could prevent an additional 9-14% of deaths. We found that administering an additional dose of RV1 might be an effective strategy to improve rotavirus vaccine impact, particularly in settings with low vaccine effectiveness.