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Data from: Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice

Data files

Apr 07, 2025 version files 76.82 KB

Abstract

Polychlorinated biphenyls (PCBs) are toxicants present in the environment and are linked to numerous adverse health effects; however, impacts of developmental PCB exposure on lower urinary tract function are understudied. We have previously found developmental exposure (in utero and lactational) to a human-relevant PCB mixture in mice leads to sex- and dose- dependent changes to urinary voiding physiology at 6 weeks of age. This study expands upon previous findings to investigate if developmental PCB-induced urinary voiding phenotypes persist or shift as mice age to 12 weeks of age. Urinary voiding physiology testing through void spot assays, uroflowmetry, and cystometry demonstrated several sex- and dose- dependent effects of PCB exposure at 12 weeks of age. This study demonstrates developmental exposure to PCBs continues to impact lower urinary tract function in adulthood to at least 12 weeks of age both during homeostatic conditions and upon challenge of capsaicin in mice. Better understanding of how early life stressors like PCBs contribute to aging-associated voiding dysfunction are imperative as these findings may help mitigate risk or improve treatment strategies for patients suffering from lower urinary tract symptoms. This dataset provides the raw data for mouse void spot assays, uroflowmetry, cystometry and tissue mass endpoints for manuscript: "Developmental Polychlorinated Biphenyl (PCB) Exposure Impacts on Voiding Physiology Persist into Adulthood and Influence Sensitivity to Bladder Stimuli in Mice". The data is provided in an excel speadsheet and each tab of the spreadsheet represents the raw data from each endpoint assessed including void spot assay, uroflowmetry, cystometry, cystometry with capsaicin, and tissue and body mass. These data correspond to each figure in the manuscript. The data are organized by PCB treatment group and littermates are entered into subcolumns within each treatment group to allow for nesting of the data to account for litter effects.