Data from: Common protein-coding variants and the racing phenotype in galloping racehorse breeds
Data files
Oct 18, 2022 version files 8.19 KB
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README.md
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SourceDataForFigure2.csv
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Oct 28, 2022 version files 27.62 KB
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README.md
567 B
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SourceDataForFigure2-update.xlsx
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Abstract
Centuries-long selection for system-wide morphological, physiological, and metabolic adaptations has led to extreme athletic phenotypes among geographically diverse horse breeds. Here, we identify genes contributing to exercise adaptation in racehorses by applying genomics approaches for racing performance, an end-point athletic phenotype. Using an integrative genomics strategy to first combine population genomics results with skeletal muscle exercise and training transcriptomic data, followed by whole-genome resequencing of Asian horses, we identify protein-coding variants in genes of interest in galloping racehorse breeds (Arabian, Mongolian and Thoroughbred). A core set of genes, G6PC2, HDAC9, KTN1, MYLK2, NTM, SLC16A1 and SYNDIG1, with central roles in muscle, metabolism, and neurobiology, are key drivers of the racing phenotype. Although racing potential is a multifactorial trait, the genomic architecture shaping the common athletic phenotype in horse populations bred for racing provides evidence for the influence of protein-coding variants in fundamental exercise-relevant genes. Variation in these genes may therefore be exploited for genetic improvement of horse populations towards specific types of racing.
The file has been generated for the figure 2 in the manuscript, “Common protein-coding variants and the racing phenotype in galloping racehorse breeds”. The fastStructure software was used to generate the file.
Microsoft Excel can be used to open the file.