Fires and plant invasions pose substantial threats to Mediterranean ecosystems, particularly in the context of a changing climate. Our study utilized a data-model integration approach to assess the response of soil organic carbon (SOC) to fires and plant invasion under three Shared Socio-Economic Pathway (SSP) scenarios (SSP1-26, SSP2-45, and SSP5-85). We parameterized the CLM-Microbe model and then investigated the individual and interactive impacts of fires and plant invasion on soil C by comparing factorial simulations of initialization (fire/no wildfire in 2021), fire module on/off, and with and without plant invasion during 2023-2100 in a Mediterranean ecosystem. The simulations indicated a marked C loss due to the 2021 wildfire, projected fires, and plant invasion across all future climate scenarios. Specifically, the 2021 wildfire, projected fires, and plant invasion reduced the SOC (0-30 cm) by 0.12, 0.26, and 0.15 kg C m^-2 under SSP1-26, 0.12, 0.30, and 0.12 kg C m^-2 under SSP2-45, and 0.12, 0.24, and 0.13 kg C m^-2 under SSP5-85, respectively. However, fires and plant invasion decreased SOC through distinct mechanisms. The effects of the 2021 wildfire occurred due to its negative legacy on the soil microbial community and, thus, litter accumulation, suppressing the formation of soil carbon via decomposition. Influences of projected fires occur via consuming fuel, suppressing carbon input to soils. In contrast, the impacts of plant invasions were due to enhanced microbial respiration, leading to C loss. These findings emphasize the need for tailored C sequestration strategies considering the disparate impacts of fires and plant invasions in the Mediterranean climate.