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The metabolic costs of meiotic drive

Bradshaw, Sasha1; Rodríguez, Enrique1; Wang, Hanting1; Yu, Cyn Thea1; De Villiers De La Noue, Cyril1; Hafezjee, Aadil1; Pomiankowski, Andrew1; Camus, M. Florencia1

Published May 22, 2025 on Dryad. https://doi.org/10.5061/dryad.t1g1jwtf3

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May 22, 2025 version files 36.92 KB

Abstract

Selfish genetic elements, such as meiotic drive genes, disrupt Mendel’s law of equal segregation by biasing their own transmission, often at a detriment to the rest of the genome. Metabolic costs of the X-linked sex-ratio (SR) meiotic drive were investigated in stalk-eyed flies (Teleopsis dalmanni). The experiments demonstrate that individuals with SR have reduced capacity for ATP synthesis. The disruption in mitochondrial function leads to compensation exhibited in increased basal metabolic rate and greater food consumption across a range of diets. The range of metabolic costs of drive was evident in males and females at a similar magnitude. The likely cause lies in the accumulation of deleterious mutations within the series of large inversions on the drive X chromosome, subject to low recombination and weak natural selection. In females, the drive chromosome had a dominant effect, with a single copy causing substantial metabolic compromise. There was little evidence of male-specific metabolic costs, nor evidence of greater effects of drive chromosomes on female metabolism. This suggests that direct metabolic costs from meiotic drive on spermatogenesis and from sexually antagonistic selection are relatively weak. Our results underscore the broad physiological impacts that selfish genetic elements have on host metabolism and fitness.