Alterations ion channel expression in prefrontal cortex of a mouse model of schizophrenia
Data files
Nov 18, 2019 version files 138.86 MB
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Nav1.2_tubulin-1.tif
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Nav1.2_tubulin-2_upper_Nav1.2_tubulin-3_lower.tif
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Nav1.2_tubulin-4_lower.tif
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Nav1.2-gel_1.tif
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Nav1.2-gel_2.tif
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NAV1.2-gel_3.tif
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NAV1.2-gel_4.tif
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Nav1.6_tubulin-1.tif
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Nav1.6_tubulin-2_upper.tif
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Nav1.6_tubulin-3.tif
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Nav1.6-1.tif
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NAV1.6-2.tif
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Nav1.6-3.tif
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SK_tubulin-1.tif
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SK_tubulin-2.tif
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SK_tubulin-3_lower.tif
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SK1-1.tif
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SK1-2.tif
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SK1-3.tif
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SK2-1.tif
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SK2-2.tif
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SK2-3.tif
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SK3-1.tif
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SK3-2.tif
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SK3-3.tif
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WB_analysis.xlsx
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WB_sample_labeling.pptx
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Abstract
Maternal immune activation (MIA) and juvenile social isolation (SI) are two most prevalent and widely accepted environmental insults that could increase the propensity of psychiatric illnesses. Using a two-hit model, we examined the impact of these two factors on expressions of voltage-gated sodium (Nav) and small conductance calcium-activated potassium (SK) channels in the prefrontal cortex (PFC). We found that MIA-SI significantly increased the expression level of Nav1.2 and SK3 channels that contribute to the somatodendritic potential and the mAHP, respectively.