Data from: Synergism, bifunctionality, and the evolution of a gradual sensory trade-off in hummingbird taste receptors
Data files
Jan 16, 2022 version files 380.92 KB
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Ancestors_R1.fasta
5 KB
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Ancestors_R3.fasta
5.04 KB
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AncestralReconstruction_R1_Alignment.fasta
51.16 KB
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AncestralReconstruction_R3_Alignment.fasta
50.98 KB
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AncestralReconstruction_TREE.newick
517 B
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AncRecons_SelectionTests.xlsx
47.88 KB
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HummingbirdData.xlsx
91.82 KB
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README.txt
6.06 KB
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SelectionTestAlignment_R1.fasta
61.32 KB
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SelectionTestAlignment_R3.fasta
60.74 KB
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SelectionTests_TREE.newick
399 B
Abstract
Sensory receptor evolution can imply trade-offs between ligands, but the extent to which such trade-offs occur and the underlying processes shaping their evolution is not well understood. For example, hummingbirds have re-purposed their ancestral savory receptor (T1R1-T1R3) to detect sugars, but the impact of this sensory shift on amino acid perception is unclear. Here, we use functional and behavioral approaches to show that the hummingbird T1R1-T1R3 acts as a bifunctional receptor responsive to both sugars and amino acids. Our comparative analyses reveal substantial functional diversity across the hummingbird radiation and suggest an evolutionary timeline for T1R1-T1R3 re-tuning. Finally, we identify a novel form of synergism between sugars and amino acids in vertebrate taste receptors. This work uncovers an unexplored axis of sensory diversity, suggesting new ways in which nectar chemistry and pollinator preferences can coevolve.