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Gene expression analysis of KRAS knockout pancreatic cancer cell line CFPAC1

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Jan 16, 2024 version files 3.02 MB

Abstract

We used CRISPR to inactivate mutant KRAS in CFPAC1 (KRASG12V) pancreatic cancer cell lines. Gene expression analysis of KRAS intact vs. knockout cells identified sets of genes involved in protein synthesis, cell differentiation, and metabolic processes, while the expression of MAPK/ERK target genes remained unperturbed.