Wilczyński, Miłosz. 2020 Jul 21. High levels of miRNA-103/107 are associated with poor outcome in case of breast cancer patients. MiRNA-103/107- DICER axis may be one of the key re...
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Hum, Nicholas, Sebastian, Aimy, Martin, Kelly, Gilmore, Sean, Byers, Stephen, Wheeler, Elizabeth, Coleman, Matthew, and Loots, Gabriela. 2020 Aug 8. Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and molecules secreted by CAFs play an important role in tum...
Hum, Nicholas R., Sebastian, Aimy, Gilmore, Sean F., He, Wei, Martin, Kelly A., Hinckley, Aubree, Dubbin, Karen R., Moya, Monica L., Wheeler, Elizabeth K., Coleman, Matthew A., and Loots, Gabriela G. 2021 Nov 22. Current pre-clinical models of cancer fail to recapitulate the cancer cell behavior in primary tumors primarily because of the lack of a deeper und...
Vrabel, Maura and Zaharoff, David. 2023 Apr 11. Focal ablation technologies are routinely used in the clinical management of inoperable solid tumors but often result in incomplete ablations leadi...
5. Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Ravi, Vidhya, Will, Paulina, Kueckelhaus, Jan, Sun, Na, Joseph, Kevin, Salie, Henrike, Vollmer, Lea, Kuliesiute, Ugne, von Ehr, Jasmin, K. Benotmane, Jasim, Neidert, Nicolas, Follo, Marie, Scherer, Florian, M. Goeldner, Jonathan, P. Behringer, Simon, Franco, Pamela, Khiat, Mohammed, Zhang, Junyi, G. Hofmann, Ulrich, Fung, Christian, L.Ricklefs, Franz, Lamszus, Katrin, Boerries, Melanie, Ku, Manching, Beck, Juergen, Sankowski, Roman, Schwabenland, Marius, Prinz, Marco, Schueller, Ulrich, Killmer, Saskia, Bengsch, Bertram, K.Walch, Axel, Delev, Daniel, Schnell, Oliver, and Heiland, Dieter. 2022 Sep 4. Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierar...
Hu, Kenneth, Krummel, Matthew, and Kersten, Kelly. 2022 Oct 16. T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive how other immune cells in the tumor microenvironment (TM...
Islam, Nazmul, Atreya, Alok, Nepal, Samata, Uddin, Kazi Jashim, Kaiser, Md. Rashed, Menezes, Ritesh G, Lasrado, Savita, and Abdullah-Al-Noman, Muhammad. 2023 Feb 13. Background: A cancer patient's quality of life (QoL) is the perception of their physical, functional, psychological, and social well-being as well ...
Padhan, Narendra, Nordling, Torbjörn E.M., Sundström, Magnus, Åkerud, Peter, Birgisson, Helgi, Nygren, Peter, Nelander, Sven, and Claesson-Welsh, Lena. 2017 Aug 5. Background: The progression of colorectal cancer (CRC) involves recurrent amplifications/mutations in the epidermal growth factor receptor (EGFR) a...
9. Single-cell expression and TCR data from CD19-specific CAR T cells in a phase I/II clinical trial
Kim, Hyunjin, Thomas, Paul G., and Crawford, Jeremy Chase. 2022 Jul 6. By leveraging single-cell transcriptome and T cell receptor (TCR) sequencing, we aimed to track the transcriptional signatures of CAR T cell clonot...
Shi, Jing, Jiao, Tao, Guo, Qian, Weng, Weining, Ma, Linjie, Zhang, Qing, Wang, Lijun, Zhang, Jianjian, Chen, Caiwei, Huang, Yaling, Wang, Mingqiao, Pan, Rong, Tang, Yanfang, Hu, Wenhao, Meng, Tao, Liu, Shu-Hui, Guo, Jun, Kong, Yan, and Meng, Xun. 2023 Sep 19. Recent advances in targeted therapy and immunotherapy have substantially improved the treatment of melanoma. However, therapeutic strategies are st...