Show simple item record Becker, Daniel J. Czirják, Gábor Á. Rynda-Apple, Agnieszka Plowright, Raina K. 2018-10-11T04:48:46Z 2018-10-11T04:48:46Z 2018-10-08
dc.identifier doi:10.5061/dryad.5618c1m
dc.identifier.citation Becker D, Czirják G, Rynda-Apple A, Plowright R (2018) Handling stress and sample storage are associated with weaker complement-mediated bactericidal ability in birds but not bats. Physiological and Biochemical Zoology, online in advance of print.
dc.description Variation in immune defense influences infectious disease dynamics within and among species. Understanding how variation in immunity drives pathogen transmission among species is especially important for animals that are reservoir hosts for zoonotic pathogens. Bats in particular have a propensity to host serious viral zoonoses without developing clinical disease themselves. The immunological adaptations that allow bats to host viruses without disease may be related to their adaptations for flight (e.g., in metabolism and mediation of oxidative stress). A number of analyses report greater richness of zoonotic pathogens in bats than in other taxa such as birds (i.e., mostly volant vertebrates) and rodents (i.e., non-volant, small mammals), but immunological comparisons between bats and these other taxa are rare. To examine interspecific differences in bacterial killing ability (BKA), a functional measure of overall constitutive innate immunity, we use a phylogenetic meta-analysis to compare how BKA responds to the acute stress of capture and to storage time of frozen samples across the orders Aves and Chiroptera. After adjusting for host phylogeny, sample size, and total microbe colony-forming units, we find preliminary evidence that constitutive innate immune defense of bats may be more resilient to handling stress and storage time than that of birds. This pattern was also similar when analyzing the proportion of non-negative and positive effect sizes per species using phylogenetic comparative methods. We discuss potential physiological and evolutionary mechanisms by which complement proteins may differ between species orders and suggest future avenues for comparative field studies of immunity between sympatric bats, birds, and rodents in particular.
dc.relation.haspart doi:10.5061/dryad.5618c1m/1
dc.relation.haspart doi:10.5061/dryad.5618c1m/2
dc.relation.isreferencedby doi:10.1086/701069
dc.subject acute stress
dc.subject bacterial killing assay
dc.subject bacterial killing ability
dc.subject ecoimmunology
dc.subject innate immunity
dc.subject wildlife
dc.title Data from: Handling stress and sample storage are associated with weaker complement-mediated bactericidal ability in birds but not bats
dc.type Article
dwc.ScientificName Escherichia coli ATCC 8739
dc.contributor.correspondingAuthor Becker, Daniel J.
prism.publicationName Physiological and Biochemical Zoology
dryad.fundingEntity DEB-1716698@National Science Foundation (United States)

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Title Becker et al PBZ tree
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Description Phylogenetic tree of bat and bird species included in the analyses derived from the Open Tree of Life (ott_id in CSV).
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Title Becker et al PBZ data CSV
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Description Individual effect size records and metadata (e.g., species order, assay type, sample type, total CFU, BKA covariate assessed).
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