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dc.contributor.author Hitchings, Matt D. T.
dc.contributor.author Coldiron, Matthew E.
dc.contributor.author Grais, Rebecca F.
dc.contributor.author Lipsitch, Marc
dc.coverage.spatial Niger
dc.date.accessioned 2019-03-14T20:59:58Z
dc.date.available 2019-03-14T20:59:58Z
dc.date.issued 2019-03-11
dc.identifier doi:10.5061/dryad.67st708
dc.identifier.citation Hitchings MDT, Coldiron ME, Grais RF, Lipsitch M (2019) Analysis of a meningococcal meningitis outbreak in Niger – potential effectiveness of reactive prophylaxis. PLOS Neglected Tropical Diseases 13(3): e0007077.
dc.identifier.uri http://hdl.handle.net/10255/dryad.200920
dc.description Background: Seasonal epidemics of bacterial meningitis in the African Meningitis Belt carry a high burden of disease and mortality. Reactive mass vaccination is used as a control measure during epidemics, but the time taken to gain immunity from the vaccine reduces the flexibility and effectiveness of these campaigns. Targeted reactive antibiotic prophylaxis could be used to supplement reactive mass vaccination and further reduce the incidence of meningitis, and the potential effectiveness and efficiency of these strategies should be explored. Methods and Findings: Data from an outbreak of meningococcal meningitis in Niger, caused primarily by Neisseria meningitidis serogroup C, is used to estimate clustering of meningitis cases at the household and village level. In addition, reactive antibiotic prophylaxis and reactive vaccination strategies are simulated to estimate their potential effectiveness and efficiency, with a focus on the threshold and spatial unit used to declare an epidemic and initiate the intervention. There is village-level clustering of suspected meningitis cases after an epidemic has been declared in a health area. Risk of suspected meningitis among household contacts of a suspected meningitis case is no higher than among members of the same village. Village-wide antibiotic prophylaxis can target subsequent cases in villages: across of range of parameters pertaining to how the intervention is performed, up to 220/672 suspected cases during the season are potentially preventable. On the other hand, household prophylaxis targets very few cases. In general, the village-wide strategy is not very sensitive to the method used to declare an epidemic. Finally, village-wide antibiotic prophylaxis is potentially more efficient than mass vaccination of all individuals at the beginning of the season, and than the equivalent reactive vaccination strategy. Conclusions: Village-wide antibiotic prophylaxis should be considered and tested further as a response against outbreaks of meningococcal meningitis in the Meningitis Belt, as a supplement to reactive mass vaccination.
dc.relation.haspart doi:10.5061/dryad.67st708/1
dc.relation.isreferencedby doi:10.1371/journal.pntd.0007077
dc.subject Meningococcal meningitis
dc.subject Ciprofloxacin
dc.subject Antibioitic prophylaxis
dc.subject Epidemic response
dc.title Data from: Analysis of a meningococcal meningitis outbreak in Niger – potential effectiveness of reactive prophylaxis
dc.type Article
dwc.ScientificName Neisseria meningititids
dc.contributor.correspondingAuthor Coldiron, Matthew E.
prism.publicationName PLOS Neglected Tropical Diseases

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Title Data for ciprofloxacin prophylaxis as meningitis outbreak response modeling study
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Description There are three separate .csv files. The first contains information relative to the villages of the study area. The second contains information relative to the households of meningitis cases. The third contains information relative to the individual meningitis cases.
Download Niger ciprofloxacin modeling study.zip (51.80 Kb)
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