Data from: Stabilization of primary cilia reduces abortive cell cyle re-entry to protect injured adult CNS neurons from apoptosis

Choi BKA, D’Onofrio PM, Shabanzadeh AP, Koeberle PD

Date Published: August 12, 2019

DOI: https://doi.org/10.5061/dryad.7dk08bc

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Title WST-8 measurement of N1E-115 activity after 5 hours of hypoxia and 5 hours of hypoxia+24 hours of normoxia
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Description This file contains is the data for Fig 1C. It includes the raw Wst-8 measurements of N1E-115 cells after 5 hours of hypoxia and 5 hours of Hypoxia+24 hours of normoxia and these measurements normalized to 100.
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Title N1E-115 survival after Ciliobrevin Treatment
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Description This file contains the WST8 measurements for N1E-115 survival after Ciliobrevin D treatment (sheet B) and N1E-115 survival after hypoxia and Ciliobrevin D treatment (sheet D).
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Title AraC purification of cortical neuron culture and neuron survival after Tubastatin A and Aurora A Inhibitor I treatment
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Description This file contains the data for fig 3. Sheet C contains the counts for cortical neurons (NeuN) and GFAP in AraC treated and non-treated cultures. Sheet E contains the data for the survival counts of Neurons injured by etoposide but treated with Tubastatin A in combination with or without AraC. Sheet F Contains the survival counts of neurons injured by etoposide but treated with Aurora A inhibitor.
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Title Measurements of primary cilia
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Description This file contains the file 6 which includes the measurements of retinal ganglion cell primary cilia length and the counts of their nuclei.
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Title IFT88 shRNA effects on neuron primary cilia length and survival after axotomy
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Description This file contains the data for fig 7. Sheet B,C contains the measurements of retinal ganglion cell primary cilia lengths after treatment with control or IFT88 shRNA. Sheet E contains survival counts of IFT88 treated RGCs after axotomy.
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Title The effects of various inhibitors and shRNAs targeting ciliary resorption on neuronal survival after axotomy
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Description This file contains is the data for Fig 8. Sheet B contains the axotomized retinal ganglion cell survival quantification after treatment with Tubastatin A or Aurora Inhibitor A. Sheet D contains the axotomized retinal ganglion cell survival quantification after treatment with HEF1, NDE1, PLK1, Kif2a shRNAs.
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When using this data, please cite the original publication:

Choi BKA, D’Onofrio PM, Shabanzadeh AP, Koeberle PD (2019) Stabilization of primary cilia reduces abortive cell cycle re-entry to protect injured adult CNS neurons from apoptosis. PLOS ONE 14(8): e0220056. https://doi.org/10.1371/journal.pone.0220056

Additionally, please cite the Dryad data package:

Choi BKA, D’Onofrio PM, Shabanzadeh AP, Koeberle PD (2019) Data from: Stabilization of primary cilia reduces abortive cell cyle re-entry to protect injured adult CNS neurons from apoptosis. Dryad Digital Repository. https://doi.org/10.5061/dryad.7dk08bc
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