Home range estimation is routine practice in ecological research. While advances in animal tracking technology have increased our capacity to collect data to support home range analysis, these same advances have also resulted in increasingly autocorrelated data. Consequently, the question of which home range estimator to use on modern, highly autocorrelated tracking data remains open. This question is particularly relevant given that most estimators assume independently sampled data. Here, we provide a comprehensive evaluation of the effects of autocorrelation on home range estimation. We base our study on an extensive dataset of GPS locations from 369 individuals representing 27 species distributed across 5 continents. We first assemble a broad array of home range estimators, including Kernel Density Estimation (KDE) with four bandwidth optimizers (Gaussian reference function, autocorrelated-Gaussian reference function (AKDE), Silverman's rule of thumb, and least squares cross-validation), Minimum Convex Polygon, and Local Convex Hull methods. Notably, all of these estimators except AKDE assume independent and identically distributed (IID) data. We then employ half-sample cross-validation to objectively quantify estimator performance, and the recently introduced effective sample size for home range area estimation ($\hat{N}_\mathrm{area}$) to quantify the information content of each dataset. We found that AKDE 95\% area estimates were larger than conventional IID-based estimates by a mean factor of 2. The median number of cross-validated locations included in the holdout sets by AKDE 95\% (or 50\%) estimates was 95.3\% (or 50.1\%), confirming the larger AKDE ranges were appropriately selective at the specified quantile. Conversely, conventional estimates exhibited negative bias that increased with decreasing $\hat{N}_\mathrm{area}$. To contextualize our empirical results, we performed a detailed simulation study to tease apart how sampling frequency, sampling duration, and the focal animal's movement conspire to affect range estimates. Paralleling our empirical results, the simulation study demonstrated that AKDE was generally more accurate than conventional methods, particularly for small $\hat{N}_\mathrm{area}$. While 72\% of the 369 empirical datasets had \textgreater1000 total observations, only 4\% had an $\hat{N}_\mathrm{area}$ \textgreater1000, where 30\% had an $\hat{N}_\mathrm{area}$ \textless30. In this frequently encountered scenario of small $\hat{N}_\mathrm{area}$, AKDE was the only estimator capable of producing an accurate home range estimate on autocorrelated data.