Interactions between species of ticks, their realised range of hosts, the pathogens they carry and transmit, as well as the geographical distribution of species in the Western Palearctic, have been obtained based on evidence published between 1970–2014. These relationships were linked to remotely-sensed features of temperature and vegetation and used to extract the network of interactions among the organisms. The resulting datasets were focussed on niche overlap among ticks and hosts, species interactions and the fraction of the environmental niche where tick-borne pathogens may circulate, as a result of interactions and environmental trait overlap. The presented datasets provide a valuable resource for researchers of tick-borne pathogens, as they conciliate the abiotic and biotic sides of their niche, allowing exploration of the importance of each species of vertebrate reservoir in the circulation of tick-transmitted pathogens at intervals of the environmental niche.