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The superior frontal sulcus in the human brain – Morphology and probability maps

Drudik, Kristina1; Petrides, Michael1

Published Oct 06, 2023; Updated Apr 08, 2024 on Dryad. https://doi.org/10.5061/dryad.6wwpzgn4x

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Oct 06, 2023 version files 96.90 MB

Abstract

The superior frontal sulcus (SFS) is a major sulcus on the dorsolateral frontal cortex that defines the lateral limit of the superior frontal gyrus. Caudally, it originates near the superior precentral sulcus (SPRS) and rostrally, it terminates near the frontal pole. The advent of structural neuroimaging has revealed that this primary sulcus shows significant variability below the surface which is not captured by the classic sulcal maps. The present investigation examined the morphological variability of the SFS in 50 individual magnetic resonance imaging (MRI) scans of the human brain that were registered to the Montreal Neurological Institute (MNI) standard stereotaxic space. Two primary morphological patterns were identified: i) the SFS was classified as either a continuous sulcus or ii) the SFS was a complex of sulcal segments. Further, the SFS showed a high probability of merging with neighboring sulci on the superior and middle frontal gyri, and these patterns were documented. In addition, the morphological variability and spatial extent of the SFS were quantified using volumetric and surface spatial probability maps. The results from the current investigation provide an anatomical framework for understanding the sulcal morphology of the SFS, which is critical for the interpretation of structural and functional neuroimaging data in the dorsolateral frontal region, as well as for improving the accuracy of neurosurgical interventions.