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Central processing of leg proprioception in Drosophila: Physiology and behavior data

Citation

Agrawal, Sweta et al. (2020), Central processing of leg proprioception in Drosophila: Physiology and behavior data, Dryad, Dataset, https://doi.org/10.5061/dryad.k3j9kd55t

Abstract

Proprioception, the sense of self-movement and position, is mediated by mechanosensory neurons that detect diverse features of body kinematics. Although proprioceptive feedback is crucial for accurate motor control, little is known about how downstream circuits transform limb sensory information to guide motor output. Here, we investigate neural circuits in Drosophila that process proprioceptive information from the fly leg. We identify three cell-types from distinct developmental lineages that are positioned to receive input from proprioceptor subtypes encoding tibia position, movement, and vibration. 13Bα neurons encode femur-tibia joint angle and mediate postural changes in tibia position. 9Aα neurons also drive changes in leg posture, but encode a combination of directional movement, high-frequency vibration, and joint angle. Activating 10Bα neurons, which encode tibia vibration at specific joint angles, elicits pausing in walking flies. Altogether, our results reveal that central circuits integrate information across proprioceptor subtypes to construct complex sensorimotor representations that mediate diverse behaviors, including reflexive control of limb posture and detection of leg vibration.

Methods

See manuscript (https://doi.org/10.7554/eLife.60299) for details. 

Funding

National Institutes of Health, Award: R01NS102333

Howard Hughes Medical Institute

Pew Charitable Trusts, Award: Scholar Award

Searle Scholars Program, Award: Scholar Award

Alfred P. Sloan Foundation, Award: Scholar Award

McKnight Endowment Fund for Neuroscience, Award: Scholar Award

UW Royalty Research Fund, Award: 112375

Klingenstein Simon Fellowship Award