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Data for: Cholinergic activity during probabilistic Pavlovian conditioning in mice

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Dec 14, 2022 version files 57.65 GB

Abstract

Cholinergic activity was monitored while mice performed a probabilistic Pavlovian conditioning task. Mice were headfixed and listened to auditory stimuli of different frequency, which signaled either likely reward and unlikely punishment, or likely punishment and unlikely reward. Cholinergic activity was measured in two ways. First, bulk calcium imaging of cholinergic neurons was performed by fiber photometry. Second, extracellular electrophysiology recordings were performed and optogenetic tagging was used to identify cholinergic neurons in task-performing mice. This dataset contains fiber photometry data, electrophysiology data and behavioral data of mice.