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Dryad

Data from: Obligate endosymbiosis explains genome expansion during eukaryogenesis

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Jul 31, 2023 version files 64.61 MB

Abstract

The endosymbiosis of an alpha-proteobacterium that gave rise to mitochondria was one of the key events in eukaryogenesis. One striking outcome of eukaryogenesis was a much more complex cell with a large genome. Despite the existence of many alternative hypotheses for this and other patterns potentially related to endosymbiosis, a constructive evolutionary model in which these hypotheses can be studied is still lacking.

Here, we present a new theoretical approach in which we focus on the consequences rather than the causes of the mitochondrial endosymbiosis. Using a constructive evolutionary model of cell-cycle regulation, we find that genome expansion and genome size asymmetry arise from emergent host–symbiont cell-cycle coordination. We also find that holobionts with large host and small symbiont genomes perform best on long timescales, and mimic the outcome of eukaryogenesis.

By designing and studying a constructive evolutionary model of obligate endosymbiosis, we uncovered some of the forces that may drive the patterns observed in nature. Our results provide a theoretical foundation for patterns related to the mitochondrial endosymbiosis, such as genome size asymmetry, and reveal evolutionary outcomes that have not been considered so far, such as cell-cycle coordination without direct communication.