Reconstructed micro-CT scan data for Griphognathus whitei NHMUK PV P56054 and Orlovichthys limnatis PIN3725-110 For: Clement, A., Challands, T., Cloutier, R., Houle, L., Ahlberg, P., Collin, S. and Long, J. Morphometric Analysis of Lungfish Endocasts Elucidates Early Dipnoan Palaeoneurological Evolution. eLife (30-08-2021-RA-eLife-73461) Griphognathus whitei (NHMUK PV P 56034). Griphognathus whitei was scanned at the Natural History Museum, UK, using a Nikon Metrology HMX ST 225 micro-CT scanner. The specimen was scanned with the following parameters: Energy 210 KeV, voxel size 102 microns, 180 degrees, 3142 proj, angle step 0.1 deg/proj, exposure time 0.5 sec/proj, object to detector 1170 mm. (filters: 2.5 mm Cu). The resulting image stack was rendered and segmented manually using Drishti and Drishti Paint 2.6.1 to produce a virtual 3D endocast. Orlovichthys limnatis (3725/110). Orlovichthys limnatis was scanned at the Palaeontological Institute, Moscow, in three sections using a Skyscan 1172 micro-CT scanner. Each section was scanned with the following parameters: Energy 100 KeV, voxel size 34.1 microns, 180 degrees, 514 proj, angle step 0.7 deg/proj, exposure time 0.79 sec/proj, object to detector 344 mm. (filters: 1 mm Al). The resulting image stacks of all specimens were combined using ImageJ and the subsequent image stack was rendered and segmented manually using Drishti and Drishti Paint 2.6.1 to produce a virtual 3D endocast. Please see GriphognathusNHMUKPVP56054_scan_settings.txt and OrlovichthysPIN3725_110_scan_settings.txt for detailed scan settings. All images are 16 bit greyscale tiff files.