Readme file for Dryad entry associated with "Genotype-by-Environment Interactions Due to Antibiotic Resistance and Adaptation in Escherichia coli" in Journal of Evolutionary Biology by Alex R. Hall Competitions.csv gives data shown in Fig. 1. Each row represents one competition between a given genotype and delta_ara. "History" gives the evolutionary history of that genotype, either resistant (against rifampicin), resistant_evolved (resistant against rifampicin and evolved for ~200 generations in LB), sensitive_evolved (no antibiotic-resistance mutation, but evolved for ~200 generations in LB; A-E denote independently evolved genotypes), or wild type (no resistance mutations, no experimental evolution). "Resistance_mutation" gives the amino acid change on rpoB for genotypes resistant to rifampicin. Each genotype is represented two or three times for independently replicated assays, or eight times for the wild type. "Selection coefficient" is calculated as described in Methods. Biolog.csv gives data used for Fig. 2 and Fig. 3. Each row represents one growth assay for a given genotype on a given substrate. "History" and "Resistance_mutation" are as above; "delta_OD" is growth score as defined in Methods. Each genotype was assayed in each environment three times independently; NA is assigned for plates on which no bacteria bacteria grew (two Biolog plates).