Data from: Virus evolution in Wolbachia-infected Drosophila
Data files
Oct 28, 2019 version files 70.83 MB
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alignment_DCV_isolates.fas
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DCV titer time-course analysis_DCV isolates.R
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DCV_snps_rc.txt
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Mantel test.R
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nls mcmc confidence intervals.R
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PCA and DAPC.R
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readsummary_overlap_allsamples_allinvariantreads.csv
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readsummary_overlap_allsamples.csv
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recombination2.R
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Sequencing data reformatting and filtering.R
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snps_by_read.R
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Virus titer data - DCV isolates.txt
Abstract
Wolbachia, a common vertically transmitted symbiont, can protect insects against viral infection and prevent mosquitoes from transmitting viral pathogens. For this reason, Wolbachia-infected mosquitoes are being released to prevent the transmission of dengue and other arboviruses. An important question for the long-term success of these programs is whether viruses can evolve to escape the antiviral effects of Wolbachia. We have found that Wolbachia altered the outcome of competition between strains of the DCV virus in Drosophila. However, Wolbachia still effectively blocked the virus genotypes that were favoured in the presence of the symbiont. We conclude that Wolbachia did cause an evolutionary response in viruses but this has little or no impact on the effectiveness of virus-blocking.