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Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma

Citation

Ní Leathlobhair, Máire et al. (2021), Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma, Dryad, Dataset, https://doi.org/10.5061/dryad.1zcrjdfsg

Abstract

Recent discoveries of transmissible cancers in multiple bivalve species suggest that direct transmission of cancer cells within species may be more common than previously thought, particularly in aquatic environments. Fibropapillomatosis occurs with high prevalence in green sea turtles (Chelonia mydas) and the geographic range of disease has increased since fibropapillomatosis was first reported in this species. Widespread incidence of schwannomas, benign tumours of Schwann cell origin, reported in aquarium-bred goldfish (Carassius auratus), suggest an infectious aetiology. We investigated the hypothesis that cancers in these species arise by clonal transmission of cancer cells. Through analysis of polymorphic microsatellite alleles, we demonstrate concordance of host and tumour genotypes in diseased animals. These results imply that the tumours examined arose from independent oncogenic transformation of host tissue and were not clonally transmitted. Further, failure to experimentally transmit goldfish schwannoma via water exposure or inoculation suggest that this disease is unlikely to have an infectious aetiology.

Usage Notes

Fragment sequence data files for five loci (A6, B103, B123, C102, D108) for tumour (T) and matched normal (N) tissues from six individual green sea turtles (GT1-GT6) afflicted with fibropapillomatosis. Two tumours (T1,T2) were sampled from individual GT2.

Funding

Wellcome Trust, Award: 10294/Z/13/A

Horizon 2020, Award: Marie Skłodowska-Curie Grant Agreement 663830-BU115

National Save the Sea Turtle Foundation

Welsh Government Office for Science

Gumbo Limbo Nature Center

Horizon 2020, Award: Marie Skłodowska-Curie Grant Agreement 663830-BU115

Welsh Government Office for Science

Gumbo Limbo Nature Center