Skip to main content
Dryad logo

Data for: The hippocampal representation of context is preserved despite neural drift

Citation

Keinath, Alexandra (2022), Data for: The hippocampal representation of context is preserved despite neural drift, Dryad, Dataset, https://doi.org/10.5061/dryad.2z34tmpp9

Abstract

The hippocampus is thought to mediate episodic memory through the instantiation and reinstatement of context-specific cognitive maps. However, recent longitudinal experiments have challenged this view, reporting that most hippocampal cells change their tuning properties over days even in the same environment. Often referred to as neural or representational drift, these dynamics raise questions about the capacity and content of the hippocampal code. One such question is whether and how these long-term dynamics impact the hippocampal code for context. To address this, we imaged large CA1 populations over more than a month of daily experience as freely behaving mice participated in an extended geometric morph paradigm. We find that long-timescale changes in population activity occurred orthogonally to the representation of context in network space, allowing for consistent readout of contextual information across weeks. This population-level structure was supported by heterogeneous patterns of activity at the level of individual cells, where we observed evidence of a positive relationship between interpretable contextual coding and long-term stability. Together, these results demonstrate that long-timescale changes to the CA1 spatial code preserve the relative structure of contextual representation.

Funding

Canadian Institutes for Health Research, Award: 367017

Canadian Institutes for Health Research, Award: 377074

Natural Sciences and Engineering Research Council of Canada, Award: 74105

Canada Research Chairs Program

Brain Canada Foundation

Natural Sciences and Engineering Research Council of Canada, Award: Banting Postdoctoral Fellowship (ATK)

Healthy Brains for Healthy Lives, Award: Postdoctoral Fellowship (ATK)