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Dryad

Imaging mass cytometry data from IDH wildtype glioblastomas

Data files

Apr 26, 2024 version files 8.01 GB
Jul 31, 2024 version files 8.01 GB

Abstract

Myeloid cells are highly prevalent in glioblastoma (GBM), existing in a spectrum of phenotypic and activation states. We now have limited knowledge of the tumor microenvironment (TME) determinants that influence the localization and the functions of the diverse myeloid cell populations in GBM. In this dataset, we have used imaging mass cytometry to identify and map the various myeloid populations in the human GBM tumor microenvironment (TME) using known markers for myeloid and neoplastic cells in GBM. Our analyses of these data found that different myeloid populations had distinct and reproducible compartmentalization patterns in the GBM TME that were driven by tissue hypoxia and varied homotypic and heterotypic cellular interactions. This dataset consists of imaging mass cytometry data (16-bit TIFF images) for 8 glioblastomas and 1 tonsil sourced from the Salford Royal NHS Trust Biobank.