Skip to main content
Dryad logo

Data from: An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura

Citation

Wedell, Nina (2019), Data from: An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura, Dryad, Dataset, https://doi.org/10.5061/dryad.37pvmcvfc

Abstract

Selfish ‘meiotic drive’ alleles are transmitted to >50% of offspring, allowing them to rapidly invade populations even if they reduce the fitness of individuals carrying them. Theory predicts that drivers should either fix or go extinct, yet some drivers defy these predictions by persisting at low, stable frequencies for decades. One possible explanation for this discrepancy is that drivers are especially costly when homozygous, although empirical tests of this idea are rare and equivocal. Here, we measure the fitness of female Drosophila pseudoobscura carrying zero, one, or two copies of the X-linked driver Sex-Ratio (SR). SR had strong negative effects on female offspring production and the probability of reproductive failure, and these effects were largely similar across four genetic backgrounds. SR was especially costly when homozygous. We used our fitness measurements to parameterise a population genetic model, and found that the female fitness costs observed here can explain the puzzlingly low allele frequency of SR in nature. We also use the model to show how spatial variation in female mating behaviour, fitness costs of SR, and the reduced siring success of SR males can jointly explain the North-South cline in SR frequencies across North America.

Usage Notes

Excel spreadsheet showing the number of offspring produced by females carrying 0 (ST/ST), 1 (SR/ST), or 2 (SR/SR) driving X chromsomes introgressed into 4 genetic backgrounds (Lew 13, Lew 17, Slo7, Slo13), with female age and body size as covariate = main data

Separate excel spreadsheet showing the total number of sons and daughters produced across the 3 genotypes and 4 genetic backgrounds = sex ratio