Synaptic organization of cortico-cortical communication in primates
Data files
Oct 27, 2019 version files 447.83 KB
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Area1_ij_infra_M.txt
6.62 KB
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Area1_ij_infra_Mo.txt
19.29 KB
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Area1_ij_infra_P.txt
19.47 KB
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Area1_ij_supra_M.txt
12.43 KB
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Area1_ij_supra_Mo.txt
18.59 KB
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Area1_ij_supra_P.txt
21.48 KB
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Area3b_ij_infra_J.txt
1.79 KB
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Area3b_ij_infra_Mc.txt
10.06 KB
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Area3b_ij_infra_V.txt
15.86 KB
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Area3b_ij_supra_J.txt
4.24 KB
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Area3b_ij_supra_Mc.txt
6 KB
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Area3b_ij_supra_V.txt
23.96 KB
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Areal_and_granular_distribution_of_large_boutons.xlsx
22.44 KB
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Bouton.data_full.series.selected.xlsx
182.25 KB
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Dinnye_MB9_Br1
3.56 KB
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dissz_VB6
16.95 KB
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Duplapocak_PB8_Br1
1.74 KB
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Gyöngy1_PB8_Br3b_c
1.92 KB
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Gyöngy2_PB8_Br3b_b
6.79 KB
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Gyöngy3_PB8_Br3b_a
5.47 KB
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Gyönyörűség_MB4_A1
861 B
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Háromszög_PB7Br1
795 B
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JB1_A3b_balvar.2
1.92 KB
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JB5_A1_3_gubanc
886 B
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Jb5_A1_3.1
856 B
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JB5_A1_3a
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JB5_A1_3b
602 B
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JB5_A1_4
309 B
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Kígyó2_PB7_Br1_2
466 B
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MB9_patch_kisbouton.1
262 B
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McB2_A3b_29_a
524 B
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McB2_A3b_29_b
524 B
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McB2_A3b_4._28_2_szep
1.67 KB
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McB2_A3b_4._28_2_szep2
1.67 KB
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McB2_A3b_szép1
558 B
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McB2_A3b_szép2
253 B
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McB3_A1_holyag
646 B
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McB3_A1_hólyag2
450 B
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McB3_A1_holyag3
609 B
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McB3_A3b_lufi
1.30 KB
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McB3_A3b_szöcske
2.08 KB
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Mo_(2)
1.45 KB
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Mo1
219 B
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Mo3.2
1.53 KB
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negyzet_Pb7_A1_kigyo
635 B
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nobody_1_PB7_Br3b
202 B
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Nobody_2_PB2_Br3b
371 B
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p_PB2_A3b
344 B
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PB2_p1
268 B
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PB2_p2
495 B
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PB2_p3
238 B
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PB2_p4
868 B
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PB2_p5
700 B
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PB4_A1_gyöngy
348 B
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PB5_A3b_kisb_3
287 B
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PB5_A3b_kisb1
132 B
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PB5_A3b_kisb2
324 B
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PB5_A3b_kisb5
365 B
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Pocakos_PB8_Br1
10.19 KB
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szemolcs_PB2_A3b
1.40 KB
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teve_PB2_Br3b
2.26 KB
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VB3_A1_kissisak
636 B
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VB3_A1_p3
869 B
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VB3_A1_p3b
1.50 KB
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VB3_A1_p4
372 B
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VB3_A1_sisak2
470 B
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VB4_A1_patch.1
1.20 KB
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VB7_A3b_2
223 B
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VB7_A3b_3
727 B
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VB7_A3b_C8_28_4
173 B
Abstract
In cortical circuitry synaptic communication across areas is based on two types of axon terminals, small and large, with modulatory and driving roles, respectively. In contrast, it is not known whether similar synaptic specializations exist for intra-areal projections. Using anterograde tracing and three-dimensional reconstruction by electron microscopy (3D-EM) we asked if large boutons form synapses in the circuit of somatosensory cortical areas 3b and 1. In contrast to observations in macaque visual cortex, light microscopy showed both small and large boutons not only in inter-areal pathways, but also in long-distance intrinsic connections. 3D-EM showed that correlation of surface and volume provides a powerful tool for classifying cortical endings. Principal component analysis supported this observation and highlighted the significance of the size of mitochondria as a distinguishing feature of bouton type. The larger mitochondrion and higher degree of perforated postsynaptic density associated with large rather than to small boutons support the driver-like function of large boutons. In contrast to bouton size and complexity, the size of the postsynaptic density appeared invariant across the bouton types. Comparative studies in human supported that size is a major distinguishing factor of bouton type in the cerebral cortex. In conclusion, the driver-like function of the large endings could facilitate fast dissemination of tactile information within the intrinsic and inter-areal circuitry of areas 3b and 1.
The dataset contains two types of data: txt files for the light microscopic (LM) maps made by Neurolucida (e.g. Area1 ij_infra_M: injection was made into area 1 and the dataset contains only the infragranular layers). "Areal and granular distribution of large boutons" excel file includes the distribution of large boutons according to LM observations.
The other main part of the dataset is electronmicroscopic data (EM). The txt files (e.g. VB3_A1_p3, ID of an individual bouton) were created by Reconstruct software and they contain tracing information by boutons with full series separately. "Bouton.data_full.series.selected" excel file contains all of the ultrastructural futures, which was extracted from Reconstruct and derived and measured data used for our analyses.
Row data of a few boutons are missing in the dataset. The reason is those tracing work made in the past at my previous institution in my previouis computer, which was broken in the last year.