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Environmental robustness of the global yeast genetic interaction network

Citation

Costanzo, Michael et al. (2021), Environmental robustness of the global yeast genetic interaction network, Dryad, Dataset, https://doi.org/10.5061/dryad.3r2280gfd

Abstract

Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel differential interactions, which often uncovered new functional connections between distantly related gene pairs. However, the majority of observed genetic interactions remained unchanged in different conditions, suggesting that the global yeast genetic interaction network is robust to environmental perturbation and captures the fundamental functional architecture of a eukaryotic cell.

Funding

National Science Foundation, Award: DBI\0953881

National Institutes of Health, Award: R01HG005853

National Institutes of Health, Award: R01HG005084

Canadian Institutes of Health Research, Award: FDN-143264

Canadian Institutes of Health Research, Award: FDN-143265