Skip to main content
Dryad logo

Data from: Insulin-insensitivity of male genitals maintains reproductive success in Drosophila

Citation

Dreyer, Austin P.; Shingleton, Alexander W. (2019), Data from: Insulin-insensitivity of male genitals maintains reproductive success in Drosophila, Dryad, Dataset, https://doi.org/10.5061/dryad.44bm68r

Abstract

For most arthropod species, male genital size is relatively implastic in response to variation in developmental nutrition, such that the genitals in large well-fed males are similar in size to those in small poorly-fed males. In Drosophila melanogaster, reduced nutritional plasticity of the male genitalia is a consequence of low insulin sensitivity through a tissue-specific reduction in expression of FOXO, a negative growth regulator. Despite an understanding of the proximate developmental mechanisms regulating organ size, the ultimate evolutionary mechanisms that may have led to reduced FOXO expression in the genitalia have not been fully elucidated. Here we show that restoring FOXO activity in the developing genitalia reduces male genital size and decreases various aspects of male reproductive success. These data support the hypothesis that sexual selection has acted on the male genitalia to limit their nutritional plasticity through a reduction in FOXO expression, linking proximate with ultimate mechanisms of genital evolution.

Usage Notes

Funding

National Science Foundation, Award: NSF cooperative agreement No. DBI-0939454