Data from: Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin
Cardoso, Beatriz D., University of Minho
Rio, Irina S.R., University of Minho
Rodrigues, Ana Rita O., University of Minho
Fernandes, Francisca C.T., University of Minho
Almeida, Bernardo G., University of Minho
Pires, Ana, IFIMUP/IN - Instituto de Nanociência e Nanotecnologia, R. Campo Alegre, 4169-007 Porto, Portugal
Pereira, André M., IFIMUP/IN - Instituto de Nanociência e Nanotecnologia, R. Campo Alegre, 4169-007 Porto, Portugal
Araújo, João P., IFIMUP/IN - Instituto de Nanociência e Nanotecnologia, R. Campo Alegre, 4169-007 Porto, Portugal
Castanheira, Elisabete M.S., University of Minho
Coutinho, Paulo J.G., University of Minho
Published Sep 14, 2018 on Dryad.
Cite this dataset
Cardoso, Beatriz D. et al. (2018). Data from: Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin [Dataset]. Dryad. https://doi.org/10.5061/dryad.482q2rh
Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior, with a maximum magnetization of 16.2 emu/g, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.
Data supporting Table 1_SQUID measurements
Experimental results of SQUID measurements supporting data in Table 1 - Magnetic properties of magnesium ferrite nanoparticles
Curcumin emission using polarized light_Table 2
Fluorescence spectra obtained using polarized light for curcumin fluorescence steady-state anisotropy determination. Data supporting Table 2 - Anisotropy of curcumin in the several nanosystems.
Experimental measurements of curcumin fluorescence emission spectra for determination of encapsulation efficiencies. Data supporting Table 3